Evidence map›Paper›PMID 42569008›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Arterial stiffness and risk of dementia in late life: The ARIC neurocognitive study.

Jenna Barbee, James Russell Pike, Jingkai Wei, Hirofumi Tanaka, David S Knopman, Anna Kucharska-Newton, A Richey Sharrett, Timothy M Hughes, Kunihiro Matsushita, Thomas H Mosley and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jenna BarbeeDepartment of Epidemiology Gillings School of Global Public Health University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.ORCID https://orcid.org/0000-0002-6024-5224
James Russell PikeOptimal Aging Institute New York University Grossman School of Medicine New York New York USA.
Jingkai WeiDepartment of Family and Community Medicine McGovern Medical School, UTHealth Houston Houston Texas USA.
Hirofumi TanakaDepartment of Kinesiology and Health Education College of Education University of Texas at Austin Austin Texas USA.
David S KnopmanDepartment of Neurology Mayo Clinic Rochester Minnesota USA.
Anna Kucharska-NewtonDepartment of Epidemiology Gillings School of Global Public Health University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
A Richey SharrettDepartment of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA.
Timothy M HughesDepartment of Internal Medicine Wake Forest University School of Medicine Winston-Salem North Carolina USA.
Kunihiro MatsushitaDepartment of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA.
Thomas H MosleyThe MIND Center University of Mississippi Medical Center Jackson Mississippi USA.
Michelle L MeyerDepartment of Emergency Medicine UNC School of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
Priya PaltaDepartment of Neurology UNC School of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Cardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
ARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4M
Blood Pressure and ADRD in African Americans: the Jackson Heart StudyR01AG066134 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PALTA, PRIYA · 2019 to 2023
$7.2M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00003 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2022 to 2025
$5.1M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 2022 to 2025
$5.0M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00004 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI WINDHAM, BEVERLY GWEN · 2022 to 2025
$4.8M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00002 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CORESH, JOSEF · 2022 to 2025
$4.7M
NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS T32 HL007055NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIA NIH HHS R01 AG066134
6 · The paper itself

Abstract

introductionAssociations of arterial stiffness, measured through pulse wave velocity (PWV), with incident dementia may be driven by age-related structural changes to the arterial wall or by elevated blood pressure.

methodsDementia-free White or Black participants in the community-based Atherosclerosis Risk in Communities (ARIC) cohort study with measures of PWV were examined. The associations of carotid-femoral PWV (cfPWV) and total, structural, and load-dependent PWV with dementia were estimated using Poisson regression models and Cox proportional hazards models. Dementia cases were defined by physician-adjudicated review, telephone interviews, hospitalization records, and death certificates.

resultsOf 4818 participants included in the study population (mean age: 75 years; 41% male, 21% Black), 1067 (22%) developed dementia over a median follow-up of 9.0 years. Higher cfPWV, total PWV, structural PWV, and load-dependent PWV were associated with greater dementia risk. DISCUSSION: Both structural and pressure-related arterial stiffness mechanisms may underlie the link between PWV and dementia.

Indexed as

arterial stiffnesscarotid‐femoral PWV (cfPWV)dementiaload‐dependent PWVpulse wave velocity (PWV)structural PWV

Identifiers

PMID42569008
PMCPMC13448772

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.