ArticleBiochemistry and biophysics reports2026
The effect of liposomal ellagic acid on the biological properties of dental restorative materials: An in vitro comparative study.
Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated whether incorporating liposomal ellagic acid (LEA) could enhance the biological performance of two common dental restorative materials. LEA nanoparticles were synthesized and applied (10 μg/mL) to nano-glass ionomer and nano-dental cement discs. Human gingival fibroblasts were used to assess cytocompatibility, cell adhesion, inflammatory cytokine production, and oxidative stress. LEA-modified materials maintained over 96% cell viability, increased adhesion by 1.3-fold at day 3, and markedly reduced IL-6 and TNF-α levels compared to unmodified controls. Oxidative stress markers, including reactive oxygen species and malondialdehyde, were significantly decreased in treated groups. A sustained release profile (56% at 72 h) confirmed stable delivery from the restorative matrix. These findings suggest that LEA incorporation may enhance the antioxidant and anti-inflammatory profile of restorative materials while enhancing biocompatibility, supporting its potential as a bioactive additive for next-generation therapeutic restoratives.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.