ArticleACS omega2026
Metabolic Profiling Reveals PM2.5- and PM10-Induced Vitamin and Oxidative Stress Pathway Alterations Associated with Developmental Toxicity in Zebrafish Embryos.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Particulate matter (PM) is a global air pollutant causing respiratory pathology and systemic effects through bloodstream distribution, including placental transfer that potentially disrupts fetal development. Zebrafish, with rapid development and 82% orthology to human genes, provide an excellent model for studying the developing embryo. This study investigated the effects of PM2.5 and PM10 at 500 and 1000 μg/mL during embryogenesis (4-50 h postfertilization). PM2.5 exposure uniquely caused a 22 h hatching delay, suggesting developmental disruption. Untargeted metabolomics via LC-MS/MS was employed to investigate underlying mechanisms. Principal component analysis revealed distinct clustering by concentration (PC1, PC2) and particle size (PC1, PC3). Volcano plot analysis identified more altered metabolites (>2-fold change,
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.