ArticlePhysics and imaging in radiation oncology2026
Base of tongue volume and dose as predictors of late dysphagia after definitive or adjuvant radiotherapy for oral cavity squamous cell carcinoma.
Article in Physics and imaging in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and purpose: Radiation-induced dysphagia is a major determinant of quality of life in patients treated for oral cavity squamous cell carcinoma (OCSCC). While dose to the pharyngeal constrictor muscles has been extensively investigated, the base of tongue (BOT) remains poorly studied. This study aimed to evaluate the association between BOT volume and dose-volume parameters and late dysphagia. Material and methods: Fifty-two patients with OCSCC treated with volumetric modulated arc therapy (VMAT) between 2019 and 2023 were retrospectively analyzed. All patients had a prophylactic feeding tube (FT) placed before VMAT. The base of tongue was delineated using an artificial intelligence-based segmentation algorithm and reviewed by a senior radiation oncologist. Late dysphagia was defined as prolonged FT dependency using the cohort-specific 75th percentile (> 442.5 days). Volumetric and dose/volume parameters of the BOT (D Results: The median BOT volume for the entire cohort was 18.4 cm Conclusions: Smaller BOT volume was associated with increased risk of prolonged FT dependency after radiotherapy for OCSCC. BOT dose metrics were not significant but showed hypothesis-generating trends that warrant validation in larger cohorts and dose-optimization studies.
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