Evidence map›Paper›PMID 42569231›Full record

ArticleMaterials today. Bio2026

A nanozyme-augmented peripheral nerve-targeting liposome alleviates local immune inflammation and ferroptosis for enhanced facial nerve repair.

Qiang Zhou, Xiaolong Xu, Shuyi Lin, Yida Wang, Yuqi Han, Wenxin Liang, Ran Mo, Xianlong Wang, Yiyang Cheng, Chengxuan Tang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qiang ZhouDepartment of Neurosurgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Xiaolong XuOriental Pan-Vascular Devices Innovation College, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Shuyi LinDepartment of Neurosurgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Yida WangDepartment of Neurosurgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Yuqi HanDepartment of Neurosurgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Wenxin LiangDepartment of Neurosurgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Ran MoDepartment of Neurosurgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Xianlong WangDepartment of Neurosurgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Yiyang ChengDepartment of Neurosurgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Chengxuan TangDepartment of Spine Surgery, The Third Affiliated Hospital of Wenzhou Medical University (Ruian People's Hospital), Wenzhou, 325200, China.
Lingxiao ZhangInterdisciplinary Nanoscience Center, Aarhus University, Aarhus C 8000, Denmark.
Yiheng YangDepartment of Neurosurgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Xianzhen ChenDepartment of Neurosurgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Liangle LiuDepartment of Spine Surgery, The Third Affiliated Hospital of Wenzhou Medical University (Ruian People's Hospital), Wenzhou, 325200, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Facial nerve injury (FNI) is a common form of peripheral nerve damage that often results in incomplete functional recovery due to a hostile microenvironment characterized by excessive oxidative stress and inflammatory activation. These pathological conditions disrupt Schwann cell homeostasis, impair myelin maintenance, and hinder nerve regeneration. Although ferroptosis, an iron-dependent lipid peroxidation-driven form of regulated cell death, has been implicated in peripheral nerve disorders, its involvement in acute FNI remains not fully defined. In this study, transcriptomic analysis of injured facial nerve tissue suggested ferroptosis-related transcriptional alterations and lipid peroxidation-associated cellular injury during the acute phase of FNI, including changes in ferroptosis-related gene expression, decreased GPX4 levels, and increased 4-HNE accumulation. To modulate this complex microenvironment, we developed a peripheral nerve-targeted, ROS-responsive liposomal nanoplatform (F-MHC@PNRLs) co-delivering Ferrostatin-1 (Fer-1) and Mn-doped CeO

Indexed as

Facial nerve injuryFerroptosisFerrostatin-1Mn-doped CeO2 nanozymePeripheral nerve targetingROS-Responsive liposomesSchwann cells

Identifiers

PMID42569231
PMCPMC13449359

What Socratic holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.