Human risk taking and metabolic state: No credible evidence for desacyl-ghrelin modulation of neural or behavioural effects.

Steven Geysen, Angela M Brands, Heidrun Schultz, Julian Koenig, Marc Tittgemeyer, Jan Peters

Abstract read

In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Steven GeysenBiological Psychology, Department of Psychology, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0009-0003-1417-5127

Angela M BrandsBiological Psychology, Department of Psychology, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0000-0003-0422-8160

Heidrun SchultzCognitive Neuroscience Lab, Department of Liberal Arts and Sciences, University of Technology Nuremberg, Nuremberg, Germany.ORCID https://orcid.org/0000-0002-5287-336X

Julian KoenigDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0000-0003-1009-9625

Marc TittgemeyerMax Planck Institute for Metabolism Research, Cologne, Germany.ORCID https://orcid.org/0000-0001-5072-2149

Jan PetersBiological Psychology, Department of Psychology, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0000-0002-0195-5357

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Risk taking has often been proposed to depend on homeostatic systems. However, empirical evidence remains inconsistent, and the underlying mechanisms remain debated. Changes in risky decision-making, which are associated with homeostatic alterations, may be affected by underlying ghrelin signaling, a peptide hormone that also interacts with dopaminergic functions. The deacylated form of ghrelin has recently received increased attention. Across two studies, we examined whether experimental interventions known to alter desacyl-ghrelin levels influence risky choice in healthy male participants. In study 1, participants underwent a brief fasting period (

Indexed as

fMRIhierarchical Bayesian modellinghungerprobability discountingrisky decision makingsleep deprivation

Identifiers

PMID42569362

DOI10.1162/IMAG.a.1330

PMCPMC13449932

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.