Evidence map›Paper›PMID 42569424›Full record

ArticleInternational journal of general medicine2026

Integrative Transcriptomic Analysis and Preliminary Peripheral Blood Evaluation Identify

Cheng Luo, Chengzheng Duan, Shiyu Xu, Jiali Xu, Shengxin Wang, Lulu Zheng, Xianmei Yu, Dongjuan He

Abstract read
In one paragraph

Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cheng Luo *Department of Endocrinology and Metabolism, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, 324000, People's Republic of China.
Chengzheng Duan *Department of Endocrinology and Metabolism, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, 324000, People's Republic of China.
Shiyu XuDepartment of Endocrinology and Metabolism, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, 324000, People's Republic of China.ORCID 0009-0003-5450-9670
Jiali XuDepartment of Endocrinology and Metabolism, The Second People's Hospital of Quzhou, Quzhou, Zhejiang, 324022, People's Republic of China.
Shengxin WangDepartment of Endocrinology and Metabolism, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, 324000, People's Republic of China.ORCID 0009-0005-5218-2058
Lulu ZhengDepartment of Endocrinology and Metabolism, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, 324000, People's Republic of China.
Xianmei YuDepartment of Endocrinology and Metabolism, The Second People's Hospital of Quzhou, Quzhou, Zhejiang, 324022, People's Republic of China.ORCID 0009-0005-6672-6677
Dongjuan HeDepartment of Endocrinology and Metabolism, The Second People's Hospital of Quzhou, Quzhou, Zhejiang, 324022, People's Republic of China.ORCID 0009-0001-1750-127X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Complete androgen insensitivity syndrome (CAIS) is a rare 46,XY disorder/difference of sex development (DSD) caused by impaired androgen receptor (AR) function. Although Methods: Two CAIS-related RNA-seq datasets from the Gene Expression Omnibus (GEO) were analyzed separately rather than merged at the expression-matrix level. GSE125222 included testicular tissue from 3 CAIS cases and 3 normal-spermatogenesis controls on GPL20301/Illumina HiSeq 4000. GSE300211 included 64 genital skin fibroblast libraries from 12 control and 4 CAIS fibroblast lines treated with ethanol or 10 nM dihydrotestosterone for 48 or 72 h on GPL30173/NextSeq 2000. Differential expression analysis, weighted gene co-expression network analysis (WGCNA), least absolute shrinkage and selection operator (LASSO), random forest, and support vector machine-recursive feature elimination (SVM-RFE) were used to prioritize exploratory candidate genes. Results: Conclusion:

Indexed as

androgen receptorASAP2complete androgen insensitivity syndromeexploratory targetmachine learningperipheral blood mononuclear cellstranscriptomicsweighted gene co-expression network analysis

Identifiers

PMID42569424
PMCPMC13450085

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.