ArticleTobacco induced diseases2026
Association of metabotropic glutamate receptor 7 gene with nicotine dependence in a Chinese Han population: A cross-sectional candidate-gene association study.
Article in Tobacco induced diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionDespite a global decline in prevalence, cigarette smoking remains a significant public health issue. Tobacco addiction is principally caused by nicotine dependence (ND). This study aimed to investigate the relationship between the metabotropic glutamate receptor 7 (
methodsThis two-stage, cross-sectional, candidate-gene association study first enrolled a discovery cohort of 1609 participants from Kunming, Yunnan, China (2017-2019), followed by a replication stage involving 1329 individuals from Jincheng and Taiyuan, Shanxi, China (2012-2013). Association analysis between the
resultsRs77452956, rs74791991, and rs2176404 were significantly associated with ND proxied by HSI, with p-values of <0.001, 0.001, and 0.002, respectively. In the replication analysis, rs74791991 and rs2176404 showed associations with ND (p=0.006 and 0.082, respectively), while rs77452956 was linked to smoking status (p=0.014). Haplotype-based association analysis revealed that two haplotypes, C-C-T and T-G-C, comprising rs74791991, rs111848366, and rs7633313, were associated significantly with HSI, with p<0.001 and p=0.003, respectively. Gene-based analysis also revealed a significant association between
conclusionsWe identified three SNPs, rs74791991, rs2176404, and rs77452956, associated with ND in Han Chinese individuals. Our findings suggest a potential role of
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