Trial reportRisk management and healthcare policy2026
Effects of a Life Hope Program on Self-Care Ability and Hope Levels in Hemodialysis Patients: A Randomized Controlled Trial.
Trial report in Risk management and healthcare policy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Objective: To assess whether the Life Hope Program, when added to routine nursing care, improves self-care ability (primary outcome) and hope levels (co-primary outcome), as well as psychological well-being, nutritional status, quality of life, and complication rates in uremic patients receiving hemodialysis. Methods: In this randomized controlled trial, 120 uremic hemodialysis patients were assigned to either routine care (control, n=60) or routine care plus a 3-month Life Hope Program (study, n=60). The program integrated goal-setting, psychological support, behavioral and nutritional guidance, cognitive restructuring, and social support. The co-primary endpoints were the Exercise of Self-Care Agency Scale (ESCA) and the Herth Hope Index (HHI). Secondary outcomes included depression (SDS), anxiety (SAS), fatigue (PFS), quality of life (WHOQOL-BREF), nutritional biomarkers (hemoglobin, prealbumin, albumin, transferrin), and complications. Baseline-adjusted analysis of covariance (ANCOVA) was used as the primary analytical method, with adjusted mean differences, 95% confidence intervals (CIs) and Cohen's d effect sizes reported. Bonferroni correction was applied for the two co-primary endpoints to control family-wise Type I error; secondary endpoints are reported with nominal P values and interpreted as exploratory. Results: All 120 participants completed the study with no dropouts or missing data. At 3 months, the study group showed significantly greater improvement in ESCA (adjusted mean difference 16.4, 95% CI 11.3-21.5, Cohen's d = 1.16, large effect) and HHI (adjusted mean difference 5.7, 95% CI 3.8-7.6, Cohen's d = 1.09, large effect) compared to controls (both P<0.001, below the Bonferroni-corrected threshold of α = 0.025). Significant between-group differences favoring the study group were also observed for SDS (d=1.13), SAS (d=1.28), PFS (d=0.92), and all WHOQOL-BREF domains (all nominal P<0.001; all remained significant after FDR correction). Nutritional biomarkers improved more in the study group (all nominal P<0.01; all remained significant after FDR correction), and risks of vascular access infection (RR 0.12, 95% CI 0.02-0.96), constipation (RR 0.44, 95% CI 0.21-0.94), and dyspepsia (RR 0.45, 95% CI 0.24-0.87) were lower, while urinary tract infection rates did not differ significantly. Conclusion: The Life Hope Program was associated with significant improvements in self-care ability, hope, psychological well-being, and nutritional status in hemodialysis patients, alongside reductions in fatigue and certain complications. Given the multi-component nature of the intervention, the single-blind design, and the 3-month follow-up period, these promising findings warrant confirmation in attention-controlled trials with longer-term assessment.
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