Multimodal single-cell profiling identifies nclTECs and links chromatin remodeling to TEC differentiation and self-antigen expression modes.

Hanne Sagsveen Hjorthaug, Marte Heimli, Siri Tennebø Flåm, Benedicte Alexandra Lie

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hanne Sagsveen HjorthaugDepartment of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.

Marte HeimliDepartment of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.

Siri Tennebø FlåmDepartment of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.

Benedicte Alexandra LieDepartment of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The thymic epithelium consists of a diverse set of cells that generate tissue-restricted antigens (TRAs) for presentation to developing thymocytes, ensuring selection of functional and self-tolerant T cell receptors. Combining single-cell multimodal profiling and immunofluorescence microscopy, we characterize the cellular heterogeneity and chromatin accessibility landscape of human pediatric thymic epithelial cells (TECs) and infer regulatory programs underlying their differentiation and TRA expression. We describe a NEURL2

Indexed as

chromatin remodelingnclTECNEURL2thymic epithelium differentiationthymocyte maturationTRA expression

Identifiers

PMID42569502

DOI10.1016/j.isci.2026.116916

PMCPMC13450229

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.