ArticleNeuro-oncology advances
Spontaneous cellular senescence and stress response heterogeneity in human vestibular schwannomas.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Vestibular schwannomas (VS) are rare tumors of the eighth cranial nerve. Their complex etiology and not-well defined molecular basis prompted an investigation into cellular senescence as a contributing factor to tumor biology. Methods: Human VS and healthy peripheral nerve (PN) tissue samples, along with primary VS cultures, were analyzed using RNA sequencing (RNA-seq), senescence-associated β-galactosidase (SA-β-GAL) activity assays, RT-qPCR, western blotting, immunofluorescence, and cell viability assays. Results: RNA-seq revealed differential expression of senescence-related genes in VS compared to normal Schwann cells. SA-β-GAL-positive cells were observed in VS tissues but absent in PN. Primary VS cultures exhibited canonical features of senescence, including elevated SA-β-GAL activity, increased p16 protein levels, and upregulation of senescence-associated secretory phenotype (SASP) markers such as Conclusion: Spontaneous cellular senescence in VS is characterized by p16 upregulation and SASP amplification and is associated with impaired p53/p21 signaling and reduced responsiveness to senescence-inducing agents. These findings suggest that the senescent state of VS cells influences their stress response and may inform future strategies aimed at modulating senescence in tumor contexts.
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