Evidence map›Paper›PMID 42570070›Full record

ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2026

Antimicrobial, antibiofilm, and molecular docking evaluation of silver nanoparticles biosynthesized from Ocimum campechianum against Staphylococcus spp.

Natilene Silva Dos Santos, Nayara Andreo, Arun Kumar Jaiswal, Milena Lima Guimarães, Tania Maria Sarmento da Silva, Helinando Pequeno de Oliveira, Mateus Matiuzzi da Costa

Abstract read
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In one paragraph

Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Natilene Silva Dos SantosLaboratory of Animal Microbiology, Federal University of the São Francisco Valley (UNIVASF), Campus of Agricultural Sciences, Petrolina, Pernambuco, 56300-000, Brazil.ORCID http://orcid.org/0000-0003-1409-1364
Nayara AndreoLaboratory of Animal Microbiology, Federal University of the São Francisco Valley (UNIVASF), Campus of Agricultural Sciences, Petrolina, Pernambuco, 56300-000, Brazil.ORCID http://orcid.org/0000-0003-2829-9019
Arun Kumar JaiswalLaboratory of Animal Microbiology, Federal University of the São Francisco Valley (UNIVASF), Campus of Agricultural Sciences, Petrolina, Pernambuco, 56300-000, Brazil.ORCID http://orcid.org/0000-0003-0789-031X
Milena Lima GuimarãesLaboratory of Impedance Spectroscopy of Organic Materials, Institute of Material Sciences, Federal University of the São Francisco Valley (UNIVASF), Juazeiro, Bahia, 48902-300, Brazil.ORCID http://orcid.org/0000-0002-0550-8730
Tania Maria Sarmento da SilvaLaboratory of Chemistry, Federal Rural University of Pernambuco, Recife, 52171-900, Brazil.ORCID http://orcid.org/0000-0003-1887-2598
Helinando Pequeno de OliveiraLaboratory of Impedance Spectroscopy of Organic Materials, Institute of Material Sciences, Federal University of the São Francisco Valley (UNIVASF), Juazeiro, Bahia, 48902-300, Brazil.ORCID http://orcid.org/0000-0002-7565-5576
Mateus Matiuzzi da CostaLaboratory of Animal Microbiology, Federal University of the São Francisco Valley (UNIVASF), Campus of Agricultural Sciences, Petrolina, Pernambuco, 56300-000, Brazil. mmatiuzzicosta@gmail.com.ORCID http://orcid.org/0000-0002-9884-2112

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance and the overuse of antimicrobials have driven the search for innovative therapies, particularly those based on natural compounds and medicinal plant derivatives, aiming to develop new drugs. This study aimed to investigate the antimicrobial and antibiofilm activities of crude ethanolic extract of O. campechianum (CEE-OC), and commercial (AgNPs-C), non-commercial (AgNPs-NC), and Ocimum campechianum-biosynthesized (AgNPs-OC) silver nanoparticles, against 21 Staphylococcus spp. isolates. Antimicrobial activity of rosmarinic acid (RA) against six isolates was also determined. The minimum inhibitory concentration (MIC) of CEE-OC ranged from 6,250 to 781.25 µg/mL, showing the highest antimicrobial activity among the substances evaluated. AgNPs-OC exhibited MIC values approximately fourfold lower than those of CEE-OC. In contrast, AgNPs-C and AgNPs-NC showed no antimicrobial activity at the concentrations tested. CEE-OC and AgNPs-OC inhibited biofilm formation but had no effect on established biofilms. Molecular docking analysis suggested a potential interaction between RA and the NorA efflux pump protein. The results indicated that O. Campechianum extract and biosynthesized silver nanoparticles may represent promising antimicrobial alternatives, although further studies are needed to elucidate the mechanisms underlying their activity.

Indexed as

Antimicrobial alternativesBasilBiofilm inhibitionGreen synthesisMolecular dockingNanotechnology

Identifiers

PMID42570070

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.