Evidence map›Paper›PMID 42570202›Full record

ArticleNeurology and therapy2026

Treatment of Acute Ischemic Stroke with Intravenous Urokinase (TASK-UK): Protocol for a Multicenter, Prospective, Real-World Study.

Yongli Tao, Hui Fang, Lulu Pei, Yuan Gao, Kai Liu, Xin Wang, Rui Zhang, Zhentang Cao, Yifang Zhou, Ding Zhang and 4 more

Registry-linked trialAbstract read
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In one paragraph

Article in Neurology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06194968 (Treatment of Acute Ischemic StroKe With Intravenous UroKinase Real-world Research), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06194968 recruitingnot on this map

Treatment of Acute Ischemic StroKe With Intravenous UroKinase Real-world Research: a Multicenter, Prospective Study (TASK-UK)

TypeobservationalSponsorThe First Affiliated Hospital of Zhengzhou UniversityRan2023 to 2026Enrolled1,800ConditionsAcute Ischemic StrokeArmsUrokinase, Alteplase
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yongli TaoDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road Erqi District, Zhengzhou, 450001, Henan, China.
Hui FangDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road Erqi District, Zhengzhou, 450001, Henan, China.
Lulu PeiDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road Erqi District, Zhengzhou, 450001, Henan, China.
Yuan GaoDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road Erqi District, Zhengzhou, 450001, Henan, China.
Kai LiuDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road Erqi District, Zhengzhou, 450001, Henan, China.
Xin WangDepartment of Encephalopathy, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Rui ZhangDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road Erqi District, Zhengzhou, 450001, Henan, China.
Zhentang CaoDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road Erqi District, Zhengzhou, 450001, Henan, China.
Yifang ZhouDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road Erqi District, Zhengzhou, 450001, Henan, China.
Ding ZhangDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road Erqi District, Zhengzhou, 450001, Henan, China.
Yiwei QianDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road Erqi District, Zhengzhou, 450001, Henan, China.
Yuesong PanChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yuming XuDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road Erqi District, Zhengzhou, 450001, Henan, China.
Bo SongDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road Erqi District, Zhengzhou, 450001, Henan, China. fccsongb@zzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) and urokinase (UK) are both recommended for acute ischemic stroke (AIS) in China. Compared with rt-PA, UK is less expensive and more widely available in clinical practice.

objectiveThe Treatment of Acute Ischemic Stroke with Intravenous Urokinase (TASK-UK) study aims to investigate clinical outcomes among patients with AIS who receive UK thrombolysis, and to compare efficacy and cost-effectiveness between UK and rt-PA.

methodsTASK-UK is a multicenter, real-world observational study, with a planned sample size of 1000 patients in the UK group and 800 in the rt-PA group. This study enrolls patients with AIS who are eligible for intravenous thrombolysis from 20 participating centers and conducts follow-up until 90 days after thrombolysis. PLANNED OUTCOMES: The primary efficacy outcome is functional independence at 90 days, defined as a modified Rankin scale (mRS) score of 0-2. The primary safety outcome is symptomatic intracranial hemorrhage (sICH) occurring within 22-36 h after thrombolysis. The exploratory outcome is defined as an intergroup comparison of direct medical costs during hospitalization. DISCUSSION: The TASK-UK study will provide high-quality real-world evidence on the effectiveness and cost-effectiveness of UK thrombolysis for AIS. TRIAL REGISTRY NUMBER: NCT06194968 (ClinicalTrials.gov).

Indexed as

Acute ischemic strokeEffectivenessPharmacoeconomicsReal-world studyRecombinant tissue plasminogen activatorUrokinase

Identifiers

PMID42570202

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.