Evidence map›Paper›PMID 42570250›Full record

ArticleJournal of foot and ankle research2026

Efficacy of Vitamin C Treatment to Aid the Healing of Foot Ulcers in People With Diabetes: A Randomised, Placebo-Controlled Double-Blind Trial: The FOOT-C Study Protocol.

Michelle R Kaminski, Eleanor Thong, Shaun Mason, Gavin Abbott, Chris Lemoh, Jennifer Wong, Paige van der Pligt, Zhong Lu, Janet Golder, Jeong Hyun Kwon and 1 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of foot and ankle research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michelle R KaminskiDepartment of Podiatry, Monash Health, Melbourne, Australia.ORCID https://orcid.org/0000-0002-1133-4853
Eleanor ThongDepartment of Diabetes & Endocrinology, Monash Health, Clayton, Australia.ORCID https://orcid.org/0000-0002-4156-5150
Shaun MasonSchool of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition, Deakin University, Geelong, Australia.ORCID https://orcid.org/0000-0002-6138-2239
Gavin AbbottSchool of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition, Deakin University, Geelong, Australia.ORCID https://orcid.org/0000-0003-4014-0705
Chris LemohDepartment of Medicine, Western Health, Melbourne Medical School, The University of Melbourne, Melbourne, Australia.ORCID https://orcid.org/0000-0002-8383-9471
Jennifer WongDepartment of Diabetes & Endocrinology, Monash Health, Clayton, Australia.
Paige van der PligtSchool of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition, Deakin University, Geelong, Australia.ORCID https://orcid.org/0000-0003-4391-9431
Zhong LuDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia.
Janet GolderWorkforce, Innovation, Strategy, Education and Research (WISER) Unit, Allied Health, Monash Health, Melbourne, Australia.ORCID https://orcid.org/0009-0003-3697-8182
Jeong Hyun KwonDepartment of Podiatry, Monash Health, Melbourne, Australia.
Glenn D WadleySchool of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition, Deakin University, Geelong, Australia.ORCID https://orcid.org/0000-0002-6617-4359

Funding

Diabetes Australia Y24G-WADG
6 · The paper itself

Abstract

introductionDiabetes-related foot ulceration (DFU) is a serious complication, serving as a leading cause of amputation, disability, hospitalisation and a significant contributor to healthcare costs. Deficiencies in vitamin C and other micronutrients are common in DFU. Emerging evidence suggests vitamin C supplementation may enhance wound healing; however, high-quality randomised controlled trials are lacking. Therefore, the aim of this study is to investigate the efficacy of oral vitamin C supplementation (1 g/day) for 8 weeks on wound healing in people with DFU.

methodsThis is a multi-site, parallel group, randomised, placebo-controlled, double-blind trial. Eighty adults with DFU will be recruited and randomly assigned to either placebo or vitamin C supplementation (500 mg twice daily). Ulcer measurements will be obtained at baseline, 2, 4, 6 and 8 weeks with all other measures collected at baseline and 8 weeks. The primary outcome measure is the percentage reduction in ulcer size (ulcer volume in mm DISCUSSION: The findings from this research will provide high-quality evidence on the efficacy of vitamin C for wound healing in people with DFU and help to inform clinical practice regarding vitamin C supplementation alongside current standard care to aid in the healing of DFUs.

trial registrationAustralian and New Zealand Clinical Trials Registry (ACTRN12624000675527). Universal Trial Number (UTN) U1111-1308-1050.

Indexed as

Ascorbic AcidDiabetic FootVitaminsWound HealingAdultAgedDietary SupplementsDouble-Blind MethodFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicTreatment OutcomeAscorbic AcidVitaminsclinical trial protocoldiabetic footfoot ulcerrandomised controlled trialvitamin C

Identifiers

PMID42570250
PMCPMC13452466

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.