Evidence map›Paper›PMID 42570253›Full record

ArticlePsychotherapy and psychosomatics2026

Benchmarking Language Models for Clinical Safety: A Primer for Mental Health Professionals.

Matthew Flathers, Phuong Anh Nguyen, Julian Herpertz, Mason Granof, Sean Ryan, Leah Wentworth, Christine Yu Moutier, John Torous

Abstract read
In one paragraph

Article in Psychotherapy and psychosomatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew FlathersDivision of Digital Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Phuong Anh NguyenDivision of Digital Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Julian HerpertzDivision of Digital Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Mason GranofDivision of Digital Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Sean RyanDivision of Digital Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Leah WentworthNational Alliance on Mental Illness (NAMI), Arlington, Virginia, USA.
Christine Yu MoutierAmerican Foundation for Suicide Prevention (AFSP), New York, New York, USA.
John TorousDivision of Digital Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA, jtorous@bidmc.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMillions of people use language models to discuss mental health concerns, including suicidal ideation, but limited frameworks exist for evaluating whether these systems respond safely. Benchmarking, the practice of administering standardized assessments to language models, offers direct parallels to clinical competency evaluation, yet few clinicians are involved in designing, validating, or interpreting these assessments. This study aims to introduce mental health professionals to benchmarking language models by administering a validated clinical instrument and demonstrating how configuration decisions, measurement limitations, and scoring context affect result interpretation.

methodsWe administered the Suicide Intervention Response Inventory (SIRI-2) programmatically to nine commercially available language models from three providers. Each item was presented 60 times per model (three prompt variants × two temperature settings x 10 repetitions), yielding 27,000 individually scored responses compared against point-in-time expert consensus.

resultsTotal scores ranged from 19.5 to 84.0 (expert panel baseline: 32.5). Prompt design alone shifted individual model scores by as much as the difference between trained and untrained human groups. The best performing model approached the instrument's measurement floor. All nine models consistently overrated clinically inappropriate responses that sounded supportive.

conclusionA single benchmark score can support markedly different claims depending on the assumed standard of clinical behavior, the instrument's remaining measurement range, and the configuration that produced the result. The skills required to make these distinctions must become core competencies. Benchmark results are increasingly utilized to support claims about mental health safety that may not be accurate, making it necessary to close the gap between clinical measurement and AI.

Indexed as

AI safetyBenchmarkingClinical assessmentLarge language modelsSuicide intervention

Identifiers

PMID42570253
PMCPMC13641743

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.