Evidence map›Paper›PMID 42570266›Full record

ArticleChemistry & biodiversity2026

Pinus pinea L. Periderm as a Sustainable Source of Phenolic Bioactives: Integrated Phytochemical, Antioxidant, and Elemental Investigation.

Vlad Sebastian Popescu, Fabjola Bilo, Eileen Mac Sweneey, Laura Borgese, Gregorio Peron, Giulia Abate, Andrea Mastinu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vlad Sebastian PopescuDepartment of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0009-0001-8468-6921
Fabjola BiloDepartment of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0001-7362-3258
Eileen Mac SweneeyDepartment of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0001-7385-7310
Laura BorgeseDepartment of Mechanical and Industrial Engineering, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0003-3486-2656
Gregorio PeronDepartment of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0002-6007-6184
Giulia AbateDepartment of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0001-9161-3475
Andrea MastinuDepartment of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0002-8862-2896

Funding

European Union D82B23003080001
6 · The paper itself

Abstract

Pinus pinea L. is a widespread Mediterranean conifer whose bark-derived tissues remain poorly investigated as potential sources of bioactive secondary metabolites. In this study, a hydroalcoholic crude extract of the periderm, an outer renewable bark layer compatible with sustainable collection, was evaluated as an underexplored natural matrix. HPLC-DAD identified taxifolin as the main quantified marker compound, corresponding to 21.1 mg/g of dry extract. Untargeted UPLC-QTOF-MS analysis revealed a polyphenol-rich profile, mainly represented by condensed tannins and flavonoids in ESI(-) mode, while terpenoids were more evident in ESI(+) mode. The extract showed concentration-dependent DPPH radical-scavenging activity, with an IC

Indexed as

AntioxidantsPhenolsPhytochemicalsPinusPlant ExtractsBiphenyl CompoundsCell Line, TumorCell SurvivalChromatography, High Pressure LiquidHumansHydrogen PeroxidePicratesQuercetin1,1-diphenyl-2-picrylhydrazylAntioxidantsBiphenyl CompoundsHydrogen PeroxidePhenolsPhytochemicalsPicratesPlant ExtractsQuercetintaxifolinantioxidant activityperidermPinus pineataxifolinTXRFUPLC–QTOF–MS

Identifiers

PMID42570266
PMCPMC13452542

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.