Evidence map›Paper›PMID 42570273›Full record

ArticleChemistry & biodiversity2026

The Metabolites Produced by Citrus reticulata-Derived Endophyte Aspergillus fumigatus as Potential Antifungal Agents Against Citrus Pathogens.

Wen-Zhi Shi, Feng-Shuang Wei, Quan-Liang Liu, Dong Xue, Ya-Bin Yang, Xue-Qiong Yang, Zhong-Tao Ding

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wen-Zhi ShiKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, Yunnan Characteristic Plant Extraction Laboratory, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China.
Feng-Shuang WeiKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, Yunnan Characteristic Plant Extraction Laboratory, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China.
Quan-Liang LiuKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, Yunnan Characteristic Plant Extraction Laboratory, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China.
Dong XueKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, Yunnan Characteristic Plant Extraction Laboratory, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China.
Ya-Bin YangKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, Yunnan Characteristic Plant Extraction Laboratory, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China.ORCID https://orcid.org/0000-0001-5509-4559
Xue-Qiong YangKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, Yunnan Characteristic Plant Extraction Laboratory, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China.
Zhong-Tao DingKey Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, Yunnan Characteristic Plant Extraction Laboratory, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China.

Funding

Foundation for Innovative Research Groups of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China 22267001National Natural Science Foundation of China 32360107National Natural Science Foundation of China 82460693Practical Innovation Project of Postgraduate Students in the Professional Degree of Yunnan University 20257056Science and Technology Projects of Yunnan Universities Serving Key Industries FWCY-BSPY2025022Scientific Research Fund Project of Yunnan Education Department 2025Y0042Scientific Research Fund Project of Yunnan Education Department ZC-252511866Team of Graduate Supervisors in Yunnan ProvinceYunnan Characteristic Plant Screening and R&D Service CXO Platform 2022YKZY001
6 · The paper itself

Abstract

Six new bergamotene sesquiterpenoids (1-6), one new cyclohexenone derivative (7), and nine known compounds (8-16) were isolated from Citrus reticulata-associated endophytic fungus Aspergillus fumigatus. The structures were systematically established mainly by NMR data, HRESIMS, DP4+ analysis, and ECD calculations. Compounds 2-6 were proposed to be derived from β-trans-bergamotene via C-5/C-6 skeletal cleavage and further modifications. Among them, compounds 2 and 3 represent the first reported instances of the β-bergamotene derivatives bearing an epoxide moiety, characterized by unique 6/5/3 and 6/6/3 tricyclic frameworks based on oxabicyclo[3.2.1]octane and oxabicyclo[3.3.1]nonane cores, respectively. Antifungal activities against two citrus pathogens, Fusarium graminearum and Alternaria alternata, revealed that most compounds exhibited significant antifungal activities, with MIC values of 1-8 µg/mL. Notably, the antifungal activities of compounds 8 and 9 against A. alternata and compound 14 against F. graminearum were comparable to those of nystatin.

Indexed as

AlternariaAntifungal AgentsAspergillus fumigatusCitrusEndophytesFusariumMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAntifungal Agentsantifungal activityAspergillus fumigatuscitrus pathogensCitrus reticulatasecondary metabolites

Identifiers

PMID42570273
PMCPMC13452483

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.