ArticleDiabetologia2026
High prevalence of low faecal elastase levels in individuals with type 1 diabetes is associated with diabetes duration but not with marked alterations in food intake or clinical symptoms.
Article in Diabetologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aims/hypothesisAlthough exocrine pancreatic insufficiency (EPI) is thought to be common in type 1 diabetes, little is known about the relationship of EPI with type 1 diabetes parameters or food intake and abdominal complaints. Characterising individuals with EPI could help prevent EPI-related complications such as malabsorption and osteoporosis.
methodsIn a cross-sectional cohort of 443 individuals with type 1 diabetes (62% female, median age 42 years [IQR 29-54], mean BMI 25±4 kg/m
resultsThe mean FE level (±SD) was 349.5±146.8 µg/g faeces. A number of variables were independently associated with lower FE levels: older age (-10.97 µg/g faeces per 10 years; 95% CI -21.02, -0.92), longer diabetes duration (-13.09 µg/g per 10 years; 95% CI -23.54, -2.64), higher HbA CONCLUSIONS/
interpretationThe lack of evidence for associations with clinical parameters in this relatively healthy population of individuals with type 1 diabetes does not support the use of FE for routine screening for EPI. However, the high prevalence of low FE levels and their association with lower food intake and higher glucose levels justify a need for clinical awareness for EPI and its complications, especially in individuals with long diabetes duration.
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