Evidence map›Paper›PMID 42570957›Full record

ArticleScientific reports2026

Type 2 diabetes is associated with clinical progression of aortic stenosis: a nationwide retrospective study in Sweden.

Silvana Kontogeorgos, Annika Rosengren, Oskar Angerås, Petur Petursson, Tatiana Zverkova Sandström, Michael Fu, Helen Sjöland, Martin Lindgren

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Silvana KontogeorgosDepartment of Molecular and Clinical Medicine/Cardiology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. silvana.kontogeorgos@vgregion.se.
Annika RosengrenDepartment of Molecular and Clinical Medicine/Cardiology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Oskar AngeråsDepartment of Molecular and Clinical Medicine/Cardiology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Petur PeturssonDepartment of Molecular and Clinical Medicine/Cardiology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Tatiana Zverkova SandströmDepartment of Molecular and Clinical Medicine/Cardiology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Michael FuDepartment of Molecular and Clinical Medicine/Cardiology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Helen SjölandDepartment of Molecular and Clinical Medicine/Cardiology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Martin LindgrenDepartment of Molecular and Clinical Medicine/Cardiology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with type 2 diabetes mellitus (T2DM) have elevated risk for aortic stenosis (AS). The impact of diabetes on prognosis and clinical progression in AS is not well documented. In this study we try to assess if patients with T2DM and AS have faster clinical progression compared to patients without diabetes. By linkage of nationwide Swedish registries, we identified 16,116 T2DM and AS individuals (cases) and compared them with 31,066 matched comparators (AS without diabetes) from general population concerning clinical progression, defined as progression from AS diagnosis to hospitalization for heart failure, aortic valve replacement, mortality, and composite outcome of these endpoints. Kaplan-Meier curves were used to compare outcomes between cases and comparators and Cox proportional hazards analyses to account for confounders. AS individuals (total 47,182, 16,116 cases and 31,066 comparators) had mean age 71 years. The cases were younger, men predominated (58% versus 53%) and had more comorbidities. During follow-up, cases had faster clinical progression- 11% higher hazard for valve replacement (95% CI 1.04-1.18), 14% higher hazard for heart failure hospitalization (95% CI 1.03-1.26) and 4% higher hazard for composite outcome (95% CI 1.01-1.08), but with no mortality excess (HR1.00, 95%CI 0.97-1.05). Preexisting T2DM seems to be linked to moderately more rapid clinical progression in AS.

Indexed as

Aortic Valve StenosisDiabetes Mellitus, Type 2AgedAged, 80 and overDisease ProgressionFemaleHeart FailureHospitalizationHumansKaplan-Meier EstimateMaleMiddle AgedPrognosisRegistriesRetrospective StudiesRisk FactorsAortic stenosisClinical progressionDiabetes mellitus

Identifiers

PMID42570957
PMCPMC13452801

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.