Synthesis and molecular docking of novel pyrazole, pyrimidine, and pyridine derivatives as potent antimicrobial, antibiofilm, and anticancer agents.

A M A Hassan, E S Essam, Selwan Hamed, M H Helal, A K El-Ziaty, Rania S Ali

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

A M A HassanDepartment of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt. ayman.mohammed@sci.asu.edu.eg.

E S EssamDepartment of Basic Science, Faculty of Technology and Education, Capital University, Cairo, Egypt.

Selwan HamedDepartment of Microbiology and Immunology, Faculty of Pharmacy, Capital University, Ain Helwan, Helwan, 11795, Egypt.

M H HelalDepartment of Chemistry, Faculty of Science, Capital University, Ain Helwan, Cairo, Egypt.

A K El-ZiatyDepartment of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt.

Rania S AliDepartment of Basic Science, Faculty of Technology and Education, Capital University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of novel antimicrobial and anticancer agents remains a priority due to rising drug resistance and high systemic toxicity of current treatments. A series of novel pyrazole (2-6), pyrimidine (7-10), and pyridine/oxazinone (11-14) derivatives were synthesized from a chalcone scaffold (1). They were evaluated for antimicrobial, antibiofilm (Pseudomonas aeruginosa), and cytotoxic (HepG2 cells) activities. Molecular docking and qRT-PCR were performed to study their mechanism. Pyrazoles 3-5 and oxazinone 13 showed potent antibacterial activity against S. aureus (MIC = 2-3.12 µg/mL). Compounds 4 and 13 effectively eradicated P. aeruginosa biofilms, achieving a ≥ 5 log

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsAntineoplastic AgentsBiofilmsPyrazolesPyridinesPyrimidinesApoptosisCell SurvivalDNA GyraseEscherichia coliHep G2 CellsHumansMicrobial Sensitivity TestsMolecular Docking SimulationPseudomonas aeruginosaAnti-Bacterial AgentsAnti-Infective AgentsAntineoplastic AgentsDNA GyrasePyrazolespyridinePyridinespyrimidinePyrimidinesAntibiofilmAntimicrobialChalconeOxazinonePyrazolePyrimidine

Identifiers

PMID42570973

DOI10.1038/s41598-026-65144-w

PMCPMC13452809

What Socratic holds

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LicenceCC BY

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