ArticleDigestive diseases and sciences2026
The Global Immune-Nutrition-Inflammation Index (GINI) in Acute Pancreatitis Severity Assessment: A Comparative Study.
Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAcute pancreatitis (AP) is a common inflammatory disease with variable clinical severity. The Global Immune-Nutrition-Inflammation Index (GINI) has shown prognostic value in oncology but has not been investigated in AP. We aimed to evaluate its value for early severity stratification in AP and to compare it with established inflammatory indices across complementary severity references.
methodsThis retrospective single-center study included 152 patients with AP treated at Erciyes University Faculty of Medicine between January 2022 and December 2025 and 164 healthy controls. Demographic, clinical, and laboratory data obtained at admission were analyzed. Disease severity was assessed primarily using the 2012 Revised Atlanta Classification, with the Ranson score and the Bedside Index of Severity in Acute Pancreatitis (BISAP) as complementary early prognostic references, and etiology was recorded (biliary vs. non-biliary). The performance of GINI and other indices was evaluated using ROC analysis, DeLong comparisons, and multivariate logistic regression.
resultsGINI showed the highest discrimination for moderately severe/severe AP (AUC 0.813, 95% CI 0.738-0.888; cut-off 3134; sensitivity 79%, specificity 77%, NPV 92%) and was significantly superior to CRP, CAR, PLR, PIV, SII and PNI (all p < 0.05). GINI was an independent predictor (OR 3.73 per SD; p < 0.001). Its performance was preserved across biliary and non-biliary etiologies (AUC 0.848 and 0.817; interaction p = 0.68). GINI also clearly separated patients from healthy controls (AUC 0.959).
conclusionGINI outperforms most conventional inflammatory and nutritional markers for predicting AP severity, is etiology-independent, and carries a high negative predictive value. It may serve as a practical adjunct for early risk stratification; multicenter prospective validation is warranted.
Indexed as
Identifiers
42570998What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.