Two-Year Efficacy of Cylindrical Annular Refractive Elements Spectacle Lenses for Myopia Control in European Children.

Purpose: To evaluate the 2-year efficacy of cylindrical annular refractive elements (CARE) spectacle lenses in slowing myopia progression in European children. Design: Multicenter, double-masked, randomized controlled trial. Participants: Children aged 6 to 13 years with documented myopia progression of at least < -0.50 diopters (D) in the preceding 12 months. Methods: Participants were assigned to CARE or single-vision lenses (SVL). Cycloplegic spherical equivalent (SE) and axial length (AL) were measured at baseline, 12, and 24 months. Main Outcome Measures: Changes in SE and AL over 24 months, and the proportion of rapid progressors (defined as SE change ≤ -0.75 D and AL increase ≥ +0.30 mm over 24 months). Results: Of the 234 enrolled children, 208 completed the 24-month follow-up. At baseline, mean age was 10.0 ± 1.9 years and mean SE was -2.20 ± 0.94 D. All participants met the inclusion criterion of documented myopia progression of at least -0.50 D in the preceding 12 months. At 12 months, CARE lenses slowed both SE and AL progression compared with SVL (both Conclusion: Cylindrical annular refractive elements lenses effectively slowed myopia progression in European children, with sustained efficacy over 2 years. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.