Evidence map›Paper›PMID 42571355›Full record

ArticleiScience2026

Adelmidrol: A novel osteogenic mineralization regulator for bone defect repair via activating the Notch pathway with drug-loaded hydrogel.

Fei Zhang, Fanchao Li, Chao Ren, Ke Zhang, Hao Li, Hong Luo, Zhihong Xie, Kun Wei, Yang Liu, Yijie Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fei ZhangDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.
Fanchao LiDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.
Chao RenDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.
Ke ZhangDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.
Hao LiDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.
Hong LuoDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.
Zhihong XieDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.
Kun WeiDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.
Yang LiuDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.
Yijie ZhangDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.
Tao WangDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.
Wuxun PengDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defect, irreversible bone loss impairing physiological functions, raises complication risks, lowers life quality and burdens healthcare, demanding effective novel repair strategies. This study aimed to screen candidate drugs promoting osteoblast (OB) osteogenic mineralization for bone defect repair. High-throughput screening identified adelmidrol from a phase 3 clinical drug library.

Indexed as

adelmidrolNotch signaling pathwayosteoblastsosteogenic mineralization

Identifiers

PMID42571355
PMCPMC13452193

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.