Evidence map›Paper›PMID 42571539›Full record

ArticleAging brain2026

Single-cell transcriptomic analysis reveals age-related remodeling of brain endothelial cells.

Hai Duc Nguyen, Summer Siddiqui, Diana G Bohannon, Robert V Blair, Hong-Wen Deng, Alexandre Prat, Woong-Ki Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging brain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hai Duc NguyenDivision of Microbiology, Tulane National Biomedical Research Center, Tulane University, Covington, Louisiana, USA.
Summer SiddiquiDivision of Microbiology, Tulane National Biomedical Research Center, Tulane University, Covington, Louisiana, USA.
Diana G BohannonDepartment of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, USA.
Robert V BlairDivision of Comparative Pathology, Tulane National Biomedical Research Center, Tulane University, Covington, Louisiana, USA.
Hong-Wen DengCenter for Biomedical Informatics & Genomics, John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Alexandre PratDepartment of Neuroscience and CRCHUM, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada.
Woong-Ki KimDivision of Microbiology, Tulane National Biomedical Research Center, Tulane University, Covington, Louisiana, USA.

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
NIH HHS P51 OD011104
6 · The paper itself

Abstract

Blood-brain barrier (BBB) integrity naturally declines with age. Brain endothelial cells (ECs) and pericytes (PCs) form the BBB, and aging impairs tight junctions, likely via altered PC-to-EC signaling. However, the molecular mechanisms underlying this impairment remain unclear. Using single-cell RNA sequencing, we profiled 68,316 brain ECs expressing 15,564 genes from young and old mice. Unsupervised clustering and annotation revealed five distinct EC subtypes-Capillary EC1, Capillary EC2, Arterial EC, Venous EC1, and Venous EC2-defined by marker genes

Indexed as

AgingAlzheimer's diseaseEndothelial cell subtypesRamp2Rasgrf2scRNA-seq

Identifiers

PMID42571539
PMCPMC13452397

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.