ArticleChemistry & biodiversity2026
Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum.
Camila S de Freitas, Eduardo Oliveira S da Silva, Daniela C Tristão, Guilherme M Antar, Daniela P Lage, Dóris M Abrão, Luciana M Ribeiro Antinarelli, Elaine S Coimbra, João Henrique G Lago, Eduardo A F Coelho
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In one paragraphArticle in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Camila S de FreitasPost-graduation Program in Health Sciences - Infectiology and Tropical Medicine, Medicine Faculty, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0001-7882-215X Daniela P LagePost-graduation Program in Health Sciences - Infectiology and Tropical Medicine, Medicine Faculty, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Dóris M AbrãoPost-graduation Program in Health Sciences - Infectiology and Tropical Medicine, Medicine Faculty, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Luciana M Ribeiro AntinarelliDepartment of Parasitology, Microbiology and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-5183-1141 Elaine S CoimbraDepartment of Parasitology, Microbiology and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0003-1005-278X João Henrique G LagoCenter of Natural Sciences and Humanities, Federal University of the ABC, Santo Andre, Sao Paulo, Brazil.
Eduardo A F CoelhoPost-graduation Program in Health Sciences - Infectiology and Tropical Medicine, Medicine Faculty, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-6681-9014 Funding
Bill and Melinda Gates Foundation INV-031830CNPq 303820/2023-3CNPq 402417/2023-2Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo a Pesquisa do Estado de Minas Gerais APQ-02167-21Fundação de Amparo a Pesquisa do Estado de Minas Gerais RED-0067-23Fundação de Amparo a Pesquisa do Estado de São Paulo 2023/12447-1Medical Research Council IMR/Y000773/1
6 · The paper itselfAbstract
Dicentrine, an aporphine alkaloid isolated from Ocotea langsdorffii, was evaluated for its in vitro antileishmanial activity against Leishmania (L.) infantum, Leishmania (L.) amazonensis, and Leishmania (V.) braziliensis. Cytotoxicity was assessed in murine peritoneal macrophages, and the mechanism of action was investigated in L. (L.) infantum promastigotes by evaluating mitochondrial membrane potential (ΔΨm), reactive oxygen species (ROS) production, and plasma membrane integrity. Dicentrine exhibited potent activity against promastigote and intracellular amastigote forms, with EC
Indexed as
AlkaloidsAntiprotozoal AgentsAporphinesLeishmania infantumMitochondriaOcoteaOxidative StressAnimalsDose-Response Relationship, DrugMacrophages, PeritonealMembrane Potential, MitochondrialMiceParasitic Sensitivity TestsReactive Oxygen SpeciesAlkaloidsAntiprotozoal AgentsAporphinesReactive Oxygen Speciesantileishmanial actiondicentrinemitochondrial membraneOcotea langsdorffiiplasma membrane
Identifiers
PMID42571703
PMCPMC13453212
What Socratic holds
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LicenceCC BY
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