Evidence map›Paper›PMID 42572744›Full record

ArticleInternational journal of general medicine2026

An Injectable AAm-DMAEMA/Alg-Ca

Shirong Gu, Xiaoxia Le, Mengchao Gu, Kaifeng Gan, Haiming Fang, Hui Shang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shirong GuDepartment of Orthopaedics, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, 315211, People's Republic of China.
Xiaoxia LeKey Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201, People's Republic of China.
Mengchao GuDepartment of Orthopaedics, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, 315211, People's Republic of China.
Kaifeng GanDepartment of Orthopaedics, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, 315211, People's Republic of China.
Haiming FangDepartment of Orthopaedics, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, 315211, People's Republic of China.
Hui ShangKey Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Intervertebral disc degeneration (IVDD) is a major cause of low back pain and imposes a significant burden on individuals and society. Bioactive materials are widely used for tissue repair. Here, we designed a calcium alginate (Alg-Ca Methods: Morphology of AAm-DMAEMA/Alg-Ca Results: AAm treatment significantly enhanced the viability and proliferation of NP cells by almost 50% percent. AAm treatment notably alleviated disc height loss, restored tissue integrity, and increased the DHI value in rat model. MRI images showed that while the endplate signal was decreased in the model group, AAm treatment increased the signal at 4 and 8 weeks post-modeling. AAm mitigated disc height loss, improved MRI signals, preserved nucleus pulposus structure, reduced fibrous tissue formation, and promoted bone formation and chondrogenesis. AAm treatment repressed the levels of TNF-α, IL-1, IL-6, and NLRP3 in NP cells. H Conclusion: AAm treatment facilitates the proliferation of NP cells, represses the inflammatory response, alleviates tissue damage, and enhances bone formation in IVDD. These results indicate that AAm-DMAEMA/Alg-Ca

Indexed as

calcium alginateextracellular matrixinflammationintervertebral disc degenerationnucleus pulposus

Identifiers

PMID42572744
PMCPMC13453375

What Socratic holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.