Trial reportNature and science of sleep2026
Efficacy of Acupuncture for Insomnia After Chemotherapy in Breast Cancer: A Randomized Sham-Controlled Trial.
Trial report in Nature and science of sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Post-chemotherapy insomnia is a prevalent complication among breast cancer patients. No relevant sham-controlled studies have employed polysomnography to objectively verify acupuncture treatment effects. This single-blind randomized controlled trial assessed the short-term therapeutic effect and safety of acupuncture for insomnia occurring after breast cancer chemotherapy. Patients and Methods: This single-center study recruited 76 patients diagnosed with stage I-III breast cancer. All participants completed chemotherapy treatment, fulfilled ICSD-3 chronic insomnia diagnostic standards, and conformed to the TCM syndrome of Yin deficiency with excessive fire. Subjects were allocated into acupuncture group and sham acupuncture group at a 1:1 ratio with sealed opaque envelope randomization. The research spanned 9 months, including 5 weeks of biweekly intervention with 10 treatment sessions, alongside follow-up visits conducted at one week and one month after treatment termination. Clinical assessments were carried out at baseline, treatment completion, 1-week and 1-month follow-up. The primary outcome was Insomnia Severity Index score. Secondary outcomes contained PSQI, polysomnographic parameters, BAI, BDI, BFI-C and TCMSRS. All 76 randomized participants (38 cases per group) were analyzed based on intention-to-treat approach via MMRM statistical model. Results: Baseline clinical features showed no statistical difference between two groups (all Conclusion: Acupuncture improved insomnia severity, sleep quality, PSG-measured sleep architecture (increased sleep efficiency and N3, reduced WASO), fatigue, and TCM pattern symptoms in breast cancer patients with post-chemotherapy insomnia and the Yin deficiency with excessive fire syndrome; however, the between-group difference for the primary outcome did not reach the minimal clinically important difference; therefore, a clinically meaningful advantage over sham cannot be concluded from the current data. Clinical Trial Registration: China Clinical Trial Registry, https://www.chictr.org.cn/; registration number: ChiCTR2400082110.
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