Evidence map›Paper›PMID 42573890›Full record

ArticleEndocrine2026

Common genetic variants in dyslipidemia, inflammation, and angiogenesis pathways associated with diabetic nephropathy in Tunisians.

Amira Moussa, Jabeur Methnani, Refka Hassine, Houwaida Abbes, Mariem Ammar, Wided Bjaoui, Sonia Triki, Afifa Koubaa, Dorra Amor, Nabila Ben Rejeb and 4 more

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Article in Endocrine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Amira MoussaBiochemistry Department, Sahloul University Hospital, Sousse, LR12SP11, Tunisia. moussaamira@ymail.com.
Jabeur MethnaniBiochemistry Department, Sahloul University Hospital, Sousse, LR12SP11, Tunisia.
Refka HassineBiochemistry Department, Sahloul University Hospital, Sousse, LR12SP11, Tunisia.
Houwaida AbbesBiochemistry Department, Sahloul University Hospital, Sousse, LR12SP11, Tunisia.
Mariem AmmarBiochemistry Department, Sahloul University Hospital, Sousse, LR12SP11, Tunisia.
Wided BjaouiBiochemistry Department, Sahloul University Hospital, Sousse, LR12SP11, Tunisia.
Sonia TrikiLaboratory of Biochemistry and Toxicology, Monastir's University Hospital, Monastir, Tunisia.
Afifa KoubaaStah Jabeur Primary Health Center, Monastir Health Group, Monastir, Tunisia.
Dorra AmorBiochemistry Department, Sahloul University Hospital, Sousse, LR12SP11, Tunisia.
Nabila Ben RejebBiochemistry Department, Sahloul University Hospital, Sousse, LR12SP11, Tunisia.
Fadoua NeffatiLaboratory of Biochemistry and Toxicology, Monastir's University Hospital, Monastir, Tunisia.
Med-Fadhel NajjarLaboratory of Biochemistry and Toxicology, Monastir's University Hospital, Monastir, Tunisia.
Ali BouslamaBiochemistry Department, Sahloul University Hospital, Sousse, LR12SP11, Tunisia.
Asma OmezzineBiochemistry Department, Sahloul University Hospital, Sousse, LR12SP11, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDyslipidemia, inflammation and angiogenesis pathways contribute to the genetic susceptibility to diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). This study investigated the association of common genetic variants; Apolipoprotein C1 (APOC1) rs4420638, C-C chemokine receptor type 5 (CCR5) rs1799987, C-X-C motif chemokine ligand 8 (CXCL8) rs4073, Matrix metallopeptidase 9 (MMP9) rs17576, Erythropoietin (EPO) rs1617640 and Vascular Endothelial Growth Factor A (VEGFA) (rs833061 and rs3025039) with DN susceptibility in Tunisian T2DM patients. MATERIALS AND

methodsA total of 236 patients with T2DM were enrolled, including 47 with DN and 189 without diabetic nephropathy (WDN). Genotyping was performed using PCR-RFLP. Allelic combinations and statistical analyses were conducted using SNP Analyzer2.0 and SPSS20, respectively.

resultsAll genotype frequencies were in Hardy-Weinberg equilibrium. After adjustment for potential confounding factors, the variant alleles of APOC1 rs4420638 (OR = 2.58, 95% CI: 1.01-6.63, p = 0.048) and CXCL8 rs4073 (OR = 2.66, 95% CI: 1.06-6.65, p = 0.037) were independently associated with an increased risk of DN. Combined allelic profiles were associated with higher estimated DN risk, with the APOC1-CXCL8 (GT) combination showing an OR of 3.43 (95% CI: 1.08-10.80, p = 0.036).

conclusionAPOC1 rs4420638 and CXCL8 rs4073 seem to be associated with DN risk in Tunisian T2DM patients both individually and within multilocus genetic profiles.

Indexed as

AngiogenesisDiabetes Mellitus, Type 2Diabetic NephropathiesDyslipidemiasInflammationNeovascularization, PathologicAgedFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedNorth African PeoplePolymorphism, Single NucleotideAngiogenesisDiabetic nephropathyDyslipidemiaInflammationSNPTunisia

Identifiers

PMID42573890

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.