Evidence map›Paper›PMID 42573896›Full record

ArticleAdvanced biotechnology2026

A safety-aware intake modeling framework for translating edible algal biomass into nutritional bioproducts.

Yu Wang, Garrett Roell, Rica Dela Cruz, Michaela Durďáková, Jessica Maruwan, Kexin Rong, Rachel Novotny, Monica Esquivel, Lynne Wilkens, Wei Wen Su and 3 more

Abstract read
In one paragraph

Article in Advanced biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yu WangDepartment of Molecular Biosciences and Bioengineering, University of Hawai'i at Mānoa, Honolulu, Hawai'i, 96822, USA.
Garrett RoellDepartment of Molecular Biosciences and Bioengineering, University of Hawai'i at Mānoa, Honolulu, Hawai'i, 96822, USA.
Rica Dela CruzDepartment of Human Nutrition, Food and Animal Sciences, University of Hawai'i at Mānoa, Honolulu, Hawai'i, 96822, USA.
Michaela DurďákováDepartment of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 61300, Brno, Czech Republic.
Jessica MaruwanDepartment of Molecular Biosciences and Bioengineering, University of Hawai'i at Mānoa, Honolulu, Hawai'i, 96822, USA.
Kexin RongWater Resources Research Center, University of Hawai'i at Mānoa, Honolulu, Hawai'i, 96822, USA.
Rachel NovotnyDepartment of Human Nutrition, Food and Animal Sciences, University of Hawai'i at Mānoa, Honolulu, Hawai'i, 96822, USA.
Monica EsquivelDepartment of Human Nutrition, Food and Animal Sciences, University of Hawai'i at Mānoa, Honolulu, Hawai'i, 96822, USA.
Lynne WilkensUniversity of Hawai'i Cancer Center, Honolulu, Hawai'i, 96822, USA.
Wei Wen SuDepartment of Molecular Biosciences and Bioengineering, University of Hawai'i at Mānoa, Honolulu, Hawai'i, 96822, USA.
Tao YanWater Resources Research Center, University of Hawai'i at Mānoa, Honolulu, Hawai'i, 96822, USA.
Kacie HoDepartment of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 61300, Brno, Czech Republic.
Zhi-Yan DuDepartment of Molecular Biosciences and Bioengineering, University of Hawai'i at Mānoa, Honolulu, Hawai'i, 96822, USA. duz@hawaii.edu.ORCID http://orcid.org/0000-0001-7646-2429

Funding

Institute of Clinical and Translational Sciences 2021-333National Institute of Food and Agriculture 2022-38500-38099University of Hawai'i at Mānoa 23-FY23-HA-5047H-DU
6 · The paper itself

Abstract

Edible algal biomass has emerged as a promising platform for nutritional bioproduct development, but its practical translation depends on compositional variability, intake feasibility, and safety constraints. Here, we integrated biochemical profiling, trace element screening, age-specific intake modeling, and community consumption context to evaluate commercially available and supplier-provided microalgal and seaweed products within realistic application boundaries. Selected products differed substantially in macronutrient composition, fatty acid profiles, pigments, polyphenols, and mineral composition, indicating product- and species-specific roles as nutritional biomass rather than interchangeable ingredients. Across species and age groups, approximately 0.7 to 3.1 g dry biomass provided 20% of age-specific alpha-linolenic acid intake, with approximately 1 g sufficient for several products. Multi-species allocations improved omega-3 representation while remaining within practical intake limits and trace element-based screening thresholds. Community consumption data from Pacific Island children showed low and episodic seaweed intake, highlighting a gap between biomass potential and routine dietary use. These findings support safety-aware modeling as a preliminary screening and decision-support strategy for evaluating edible algal biomass before further product-specific validation.

Indexed as

Algal biotechnologyEdible algal biomassMicroalgaeNutritional bioproductsOmega-3 fatty acidsSafety-aware modeling

Identifiers

PMID42573896
PMCPMC13457825

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.