SynthesisObesity surgery2026
Alcohol-Related Liver Disease After Metabolic Bariatric Surgery: Reassessing the Hidden Risk-A Meta-Analysis.
Synthesis in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectiveTo evaluate whether metabolic bariatric surgery (MBS) influences the risk of alcohol-related liver disease (ARLD), particularly alcoholic cirrhosis, and assess its long-term hepatic implications.
methodsThis study followed PRISMA guidelines and was prospectively registered in PROSPERO. PubMed, Embase, Web of Science, Scopus, Cochrane Library, and ClinicalTrials.gov were systematically searched from inception to 26 December 2025 for observational cohort studies comparing the incidence of alcoholic cirrhosis between MBS patients and matched non-surgical controls. Data extraction and quality assessment were independently performed, and pooled effect sizes were calculated using random-effects models. Subgroup, sensitivity, and publication bias analyses were conducted. Statistical analyses were performed using Stata 17.0.
resultsFive studies were included. The overall association between MBS and alcohol-related cirrhosis was not statistically significant (OR 1.18, 95% CI 0.91-1.53; p = 0.214), with substantial heterogeneity (I² = 97.5%). However, significantly increased odds were observed in studies with sample sizes ≥ 1,000,000 and in those with follow-up durations ≥ 10 years. Leave-one-out analysis showed that no single study substantially altered the pooled estimate, and Begg's and Egger's tests detected no significant publication bias.
conclusionsCurrent evidence does not show a significant overall association between MBS and alcohol-related cirrhosis. However, substantial heterogeneity and increased odds in large-sample and long-term studies preclude firm conclusions regarding long-term hepatic safety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.