Evidence map›Paper›PMID 42575554›Full record

Trial reportBMJ open2026

Dissemination of trial results to study participants in Cambodia, Ethiopia and Pakistan: a qualitative study.

Sarah A Cassidy-Seyoum, Bipin Adhikari, Muthoni Mwaura, Asia Khan, Shan-E-Zehra Zaidi, Zahida Azizullah, Bushra Qurashi, Kansite Gellebo, Samuel Alemu Bamboro, Mom Ean and 15 more

Registry-linked trialAbstract readClinical Trial, Phase IIIEquivalence TrialMulticenter Study
In one paragraph

Trial report in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04411836 (Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine - a Randomized Controlled Trial in P. Vivax Patients), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04411836 phase3completednot on this map

Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine - a Randomized Controlled Trial in P. Vivax Patients

TypeinterventionalSponsorMenzies School of Health ResearchRan2021 to 2024Enrolled960ConditionsVivax Malaria, Plasmodium Vivax, Malaria, Vivax, Malaria RelapseArmsTafenoquine, Primaquine
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Sarah A Cassidy-SeyoumGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia sarah.cassidy-seyoum@menzies.edu.au.ORCID 0000-0003-0802-347X
Bipin AdhikariMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.ORCID 0000-0001-8981-3910
Muthoni MwauraGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Asia KhanDepartment of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, Sindh, Pakistan.
Shan-E-Zehra ZaidiDepartment of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, Sindh, Pakistan.
Zahida AzizullahDepartment of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, Sindh, Pakistan.
Bushra QurashiDepartment of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, Sindh, Pakistan.
Kansite GelleboDepartment of Sociology and Social Anthropology, Arba Minch University, Arba Minch, Ethiopia.
Samuel Alemu BamboroCollege of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia.
Mom EanMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Rupam TripuraMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Hem VattanakMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Thy VandaMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Kem SovannMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Ou SimviengMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Phal ChanpheakdeyMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Hellen MnjalaGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Grant LeeGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.ORCID 0000-0001-8495-0553
Najia GhanchiDepartment of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, Sindh, Pakistan.
Phaik Yeong CheahMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.ORCID 0000-0001-6327-3266
Ric N PriceGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
M Asim BegDepartment of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, Sindh, Pakistan.
Tamiru Shibiru DegagaGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Lek DysoleyNational Center for Parasitology Entomology and Malaria Control, Phnom Penh, Phnom Penh, Cambodia.
Kamala ThriemerGlobal and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.

Funding

Bill and Melinda Gates Foundation BMGF; INV024389Bill & Melinda Gates Foundation INV-024389Wellcome TrustWellcome Trust 315982/Z/24/Z
6 · The paper itself

Abstract

objectivesDissemination of study results to research participants is an ethical imperative, yet it is rarely implemented in resource-limited settings partly due to a lack of clear guidance. The purpose of this study was to evaluate and explore dissemination activities that were conducted as part of a multi-site clinical trial of

designQualitative study using focus group discussions (FGDs) and an inductive-deductive thematic analysis approach.

settingClinical trial study site catchment areas in Cambodia, Ethiopia and Pakistan.

participantsDissemination attendees were invited to participate in FGDs, a subset agreeing and able to participate. There were 25 participants in Cambodia, 34 in Ethiopia and 23 in Pakistan.

resultsThe dissemination activities were well accepted by participants despite some expectations in receiving individual results rather than only aggregated trial results and suggestions for broader community dissemination. Dissemination participants perceived having learnt from the dissemination, demonstrating their knowledge of the trial and its results and attributing it to the dissemination. Dissemination activities may have failed to correct certain misconceptions, including the blurred distinction between clinical care and trial-related care; however, the dissemination had positive impacts, including making participants feel part of a larger endeavour.

conclusionContributing to the limited data on dissemination in resource-limited settings, our findings provide context-informed recommendations that can be applied to similar settings. Our recommendations underscore the importance of tailoring activities according to participant preferences, such as potentially providing individual results and implementing broader community dissemination. TRIAL REGISTRATION NUMBER: NCT04411836.

Indexed as

Information DisseminationMalaria, VivaxAdultAntimalarialsCambodiaEthiopiaFemaleFocus GroupsHumansMalePakistanPlasmodium vivaxQualitative ResearchResource-Limited SettingsAntimalarialsClinical TrialCommunity ParticipationMEDICAL ETHICSQUALITATIVE RESEARCH

Identifiers

PMID42575554
PMCPMC13475131

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.