Evidence map›Paper›PMID 42575719›Full record

ArticleJournal of inherited metabolic disease2026

High-Protein Diet Ameliorates Cardiomyopathy in a Cardiac-Specific AGL Knockout Mouse Model: Association With Upregulated Hepatic Gluconeogenesis.

Caiqi Du, Hao Fu, Tingting Yu, Sisi Cao, Haotian Zhang, Boda Wei, Cai Zhang, Juan Ye, Wenjun Long, Xiaoping Luo and 1 more

Abstract read
In one paragraph

Article in Journal of inherited metabolic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Caiqi DuDepartment of Pediatrics, Tongji Children's Hospital, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0000-0002-2306-0298
Hao FuDepartment of Pediatrics, Tongji Children's Hospital, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0009-0005-9149-2382
Tingting YuDepartment of Pediatrics, Tongji Children's Hospital, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sisi CaoDepartment of Pediatrics, Tongji Children's Hospital, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0009-0000-1125-6827
Haotian ZhangDepartment of Pediatrics, Tongji Children's Hospital, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0009-0001-9715-9231
Boda WeiDepartment of Pediatrics, Tongji Children's Hospital, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Cai ZhangDepartment of Pediatrics, Tongji Children's Hospital, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0000-0001-6005-0905
Juan YeDepartment of Pediatrics, Tongji Children's Hospital, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0009-0001-5741-4867
Wenjun LongDepartment of Pediatrics, Tongji Children's Hospital, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0009-0008-2889-0910
Xiaoping LuoDepartment of Pediatrics, Tongji Children's Hospital, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0000-0002-3748-4817
Yan LiangDepartment of Pediatrics, Tongji Children's Hospital, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0000-0002-9009-3284

Funding

National Key R&D Program of China 2023YFC2706300
6 · The paper itself

Abstract

Glycogen storage disease type IIIa (GSDIIIa) causes progressive cardiomyopathy, and current high-fat dietary strategies lack consensus regarding long-term cardiovascular safety. We evaluated the efficacy and safety of high-protein versus high-fat diets in a novel cardiac-specific AGL knockout (CKO; AGL

Indexed as

CardiomyopathiesDiet, High-ProteinGluconeogenesisGlycogen Storage Disease Type IIILiverAnimalsDiet, High-FatDisease Models, AnimalGlycogenMaleMiceMice, KnockoutMyocardiumUp-RegulationGlycogencardiac‐specific AGL knockoutcardiomyopathydietary therapyglycogen storage disease type IIIhepatic gluconeogenesishigh‐protein diet

Identifiers

PMID42575719
PMCPMC13456968

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.