ArticlePediatric research2026
Percentiles for crying, regurgitation, stool consistency, and CoMiSS
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParents frequently consult health care professionals because of infant regurgitation, crying and stool consistency.
objectiveThe Cow's Milk-related Symptom Score (CoMiSS
methodsData from 2500 infants (median age 5.3 months [Q1-Q3: 2.6-8.8]) across 10 countries were analyzed by pooling individual-level data.
resultsAge distribution differed between countries (p < 0.001). Median (Q1; Q3) and mean (SD) total CoMiSS were 4 (2; 6) and 4 (2.6), respectively. Overall CoMiSS <10 was observed in 99%. Crying >3 hours/day occurred in 6.1% at 1-2 months, 4% between birth and 4 months, and <1.5% thereafter. Regurgitating > 5x/day occurred in 7-11% during the first 7 months (peak at 1-4 months: 16-17%) and decreased to <2-4% thereafter. Stool consistency accounted for 93.9% of the score. Atopic dermatitis and respiratory symptom scores are very low.
conclusionsCoMiSS is stable across age, with transiently higher crying and regurgitation scores below 4 months. CoMiSS ≥10 is uncommon in healthy infants. Age-specific CoMiSS centile charts provide a framework for interpreting common infant symptoms and identifying values warranting further evaluation. IMPACT: These data report on the prevalence of common manifestations in healthy infants and inform about normality according to age and different regions. Crying or distress and regurgitation scores are transiently more frequent during the first 4 months of life. Eczema and respiratory symptoms are seldom reported in presumed healthy infants. While caregivers and health care professionals consider regurgitation and crying or distress up to a certain limit as normal, atopic dermatitis and respiratory symptoms are not. These age-specific centile charts provide information on common infant symptoms and identify conditions that may warrant further evaluation.
Identifiers
42575964What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.