Evidence map›Paper›PMID 42576170›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Neurobiological markers across joint profiles of subjective cognitive decline and objective cognitive function in older adults.

Lu Wan, Chaeryon Kang, Rae Harrison, Patricio Solis-Urra, Kelsey R Sewell, Lauren E Oberlin, Shivangi Jain, Haiqing Huang, George Grove, M Ilyas Kamboh and 11 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02875301 (Investigating Gains in Neurocognition in an Intervention Trial of Exercise), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02875301 phase3completednot on this map

Investigating Gains in Neurocognition in an Intervention Trial of Exercise

TypeinterventionalSponsorUniversity of PittsburghRan2017 to 2023Enrolled648ConditionsHealthy, Cognitive Function 1, SocialArms150 Minutes Week, 225 Minutes Week, Stretch and Tone
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Lu WanNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
Chaeryon KangDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rae HarrisonDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Patricio Solis-UrraNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
Kelsey R SewellNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
Lauren E OberlinNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
Shivangi JainNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
Haiqing HuangNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.
George GroveDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
M Ilyas KambohDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Bradley P SuttonBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Beth E SnitzDepartment of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Arthur F KramerBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Edward McAuleyBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Jeffrey M BurnsDepartment of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Charles H HillmanDepartment of Psychology, Northeastern University, Boston, Massachusetts, USA.
Eric D VidoniDepartment of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Anna L MarslandDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Thomas K KarikariDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jill MorrisDepartment of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Kirk I EricksonNeuroscience, AdventHealth Research Institute, Orlando, Florida, USA.ORCID https://orcid.org/0000-0001-8736-981X

Funding

Investigating Gains in Neurocognition in an Intervention Trial of Exercise SupplementR01AG053952 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BURNS, JEFFREY MURRAY, ERICKSON, KIRK I · 2016 to 2020
$27.5M
Physical Activity and Dementia: Mechanisms of ActionR35AG072307 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2021 to 2025
$3.6M
NIA NIH HHS R01 AG053952NIA NIH HHS R35 AG072307NIH HHS R01 AG053952NIH HHS R35 AG072307
6 · The paper itself

Abstract

introductionSubjective cognitive concerns frequently diverge from objective cognitive performance in cognitively unimpaired (CU) older adults, yet the neurobiological basis of this mismatch remains unclear.

methodsIn 648 participants from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE), we defined four profiles by integrating subjective and objective cognitive status. We examined associations with plasma neurofilament light chain (NfL), phosphorylated tau 217 (p-tau217), glial fibrillary acidic protein (GFAP), a magnetic resonance imaging-based volumetric Alzheimer's disease (AD) signature reflecting atrophy, and brain-predicted age difference (brain-PAD).

resultsJoint profiles were differentially associated with NfL (P = 0.0427) and brain-PAD (P = 0.0296). Follow-up contrasts further indicated higher NfL and lower volumetric AD signature in the concordant lower functioning profile, and higher brain-PAD in discordant profiles. p-tau217 and GFAP did not differ across profiles. DISCUSSION: Joint subjective-objective cognitive profiles may capture biologically meaningful heterogeneity relevant to neurodegeneration and brain aging in older adults.

trial registrationClinicalTrials.gov: NCT02875301.

Indexed as

CognitionCognitive DysfunctionAgedAged, 80 and overAgingBiomarkersBrainFemaleGlial Fibrillary Acidic ProteinHumansMagnetic Resonance ImagingMaleNeurofilament ProteinsNeuropsychological Teststau ProteinsBiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament Proteinstau Proteinsagingbrain‐predicted age differencecognitively unimpaired older adultsneurodegenerationneurofilament light chainobjective cognitive functionsubjective cognitive decline

Identifiers

PMID42576170
PMCPMC13457345

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.