ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Brain morphometry patterns in the presence of Alzheimer's disease and/or LATE neuropathologic changes.
Khalid Saifullah, Abdur Raquib Ridwan, Arnold M Evia, Sue E Leurgans, Maude Wagner, David A Bennett, Julie A Schneider, Konstantinos Arfanakis
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In one paragraphArticle in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Khalid SaifullahDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA.
Abdur Raquib RidwanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Arnold M EviaRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Sue E LeurgansRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Maude WagnerRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Julie A SchneiderRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Konstantinos ArfanakisDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA.
Funding
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MRush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MCharacterizing TDP-43 related hippocampal degeneration and memory loss in agingR01AG067482 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI SCHNEIDER, JULIE A. · 2020 to 2024
$6.8MRacial Differences in Late-Life Cognitive Decline and Risk of Alzheimer's DiseaseRF1AG022018 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2016 to 2019
$6.6MMRI markers of brain aging and risk factors for cognitive decline in older African AmericansR01AG056405 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2018 to 2023
$3.6MLongitudinal validation of cerebral small vessel disease biomarkers in diverse community-based older adults without dementiaU01NS100599 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2023 to 2025
$3.5MMultimodal MRI biomarkers of small vessel disease for older persons with and without dementia.UH3NS100599 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2018 to 2020
$3.5MIn-vivo MRI-based prediction of TDP43 pathology in agingR01AG064233 · NIA · ILLINOIS INSTITUTE OF TECHNOLOGY · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2019 to 2023
$3.3MComprehensive Longitudinal Probabilistic Atlas of the Brain of Older Adults Without DementiaR01AG052200 · NIA · ILLINOIS INSTITUTE OF TECHNOLOGY · PI ARFANAKIS, KONSTANTINOS · 2016 to 2020
$2.5MInstitute of Neurological Disorders and Stroke (NINDS) U01NS100599Institute of Neurological Disorders and Stroke (NINDS) UH2-UH3NS100599NIA NIH HHS P30 AG010161NIA NIH HHS P30AG010161NIA NIH HHS P30 AG072975NIA NIH HHS P30AG072975NIA NIH HHS R01 AG015819NIA NIH HHS R01AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01AG017917NIA NIH HHS R01 AG052200NIA NIH HHS R01AG052200NIA NIH HHS R01 AG056405NIA NIH HHS R01AG056405NIA NIH HHS R01 AG064233NIA NIH HHS R01AG064233NIA NIH HHS R01 AG067482NIA NIH HHS R01AG067482NIA NIH HHS RF1 AG022018NIA NIH HHS RF1AG022018NINDS NIH HHS U01 NS100599NINDS NIH HHS UH3 NS100599
6 · The paper itselfAbstract
introductionAlzheimer's disease neuropathologic change (ADNC) and limbic-predominant age-related transactive response DNA-binding protein 43 kDa (TDP-43) encephalopathy neuropathologic change (LATENC) are common in older adults, yet differences in brain morphometry patterns when one or both pathologies are present remain unclear.
methodsWe used deformation-based morphometry on ex-vivo MRI from 912 community-based older adults to compare groups with or without ADNC and/or LATENC.
resultsAD+LATE- and AD-LATE+ groups showed less tissue in the medial temporal lobe than AD-LATE-. The AD+LATE+ group had less tissue in temporal, frontal, and parietal lobes. The AD-LATE+ group exhibited smaller anterior hippocampi than the AD+LATE- group. These findings were less pronounced in individuals without dementia. Increments in LATENC stages were associated with smaller hippocampi than increments in ADNC severity, independent of the severity of comorbid ADNC or LATENC, respectively. DISCUSSION: These findings reveal distinct and overlapping brain morphometry patterns associated with ADNC and/or LATENC, with possible implications for diagnosis in older adults.
Indexed as
Alzheimer DiseaseBrainAgedAged, 80 and overFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleAlzheimer's disease neuropathologic change (ADNC)deformation‐based morphometry (DBM)limbic‐predominant age‐related TDP‐43 encephalopathy neuropathologic change (LATENC)magnetic resonance imaging (MRI)neurodegenerationneuropathology
Identifiers
PMID42576193
PMCPMC13457351
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