ReviewFrontiers in medicine2026
Beyond pharmacotherapy: a narrative review of patient, social, and healthcare system factors influencing treatment adherence in ankylosing spondylitis.
Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease characterized by inflammatory low back pain, new bone formation, and progressive ossification of the axial skeleton. Over time, it causes irreversible structural damage to the spine and sacroiliac joints, profoundly impairing patients' quality of life and physical function. Without timely and effective intervention, AS can lead to permanent functional disability. Evidence suggests that biological, psychological, and social factors jointly undermine treatment adherence, with complex interactions among these dimensions that make single-domain interventions insufficient. Improving adherence to treatment regimens therefore requires a thorough understanding of these multifaceted influences and the development of evidence-based, multicomponent strategies. This narrative review synthesizes literature published from 2010 to 2024, drawn from PubMed/MEDLINE, Embase, Web of Science, the Cochrane Library, and CNKI, to identify factors contributing to non-adherence in AS patients, with particular attention to disease knowledge, perceptions of treatment efficacy, exercise and rehabilitation adherence, and social support. Wherever possible, evidence derived directly from AS or axial spondyloarthritis (axSpA) populations is distinguished from findings extrapolated from broader rheumatology or chronic-disease literature. Based on this synthesis, targeted recommendations for optimizing treatment management and enhancing long-term patient outcomes are proposed, together with priority directions for future AS-specific adherence research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.