ArticleFrontiers in medicine2026
Postprandial attenuation of gastric slow waves in anxiety-depression, with and without functional dyspepsia: associations with heart rate variability and sleep quality.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and aims: Functional dyspepsia (FD) commonly coexists with anxiety, depression, and sleep disturbances. However, it remains unclear whether the burden of psychological symptoms and sleep disturbances is associated with autonomic regulation and meal-induced gastric myoelectrical responses, particularly in individuals without overt FD. This study aimed to explore the relationships among heart rate variability (HRV), sleep quality, and postprandial electrogastrographic changes in adults with symptoms of anxiety-depression (AnxDep), with or without FD. Methods: A single-center cross-sectional observational study enrolled 253 participants across four clinically defined phenotypes: healthy controls ( Results: HRV indices significantly differed across groups (all Conclusion: Anxiety-depression symptoms were associated with reduced vagal-related HRV, poorer sleep quality, and a blunted postprandial gastric slow-wave response. In the anxiety-depression without FD group, a PRI < 1 reflected a blunted meal-related slow-wave response despite preserved absolute normogastria values. PRI should be considered an exploratory research endpoint requiring prospective validation.
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