ArticleFrontiers in cell and developmental biology2026
Effects of QiShenYiQi dropping pills on gut dysbiosis and statin-associated muscle symptoms in ApoE
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Statins are first-line therapeutic agents for metabolic syndrome, but their muscular adverse effects increase the metabolic burden in Type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). QiShenYiQi dropping pills (QSYQ), a compound Chinese medicine, exerts cardioprotective and metabolic regulatory effects. However, whether it is beneficial to gut microbiota dysbiosis and statin-associated muscle symptoms (SAMS) remains unclear. Methods: The disease model with T2DM complicated with CHD was established in APOE Results: Combination therapy with QSYQ markedly ameliorated glycemic and lipid profiles in animals with comorbid T2DM and CHD, and outperformed other treatment strategies in preserving hepatic and skeletal muscle function. These beneficial effects may be correlated to the regulation of gut microbiota, glycolipid metabolites and associated gene expression, including inflammation-related genes, apoptosis-related genes, as well as antioxidant and energy metabolism-related genes. Conclusion: These findings suggested the potential value of QSYQ as a promising candidate for T2DM and CHD, attenuating the side effects of statins, providing a novel complementary strategy for clinical treatment.
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