ArticleFrontiers in microbiology2026
Integrated multiomics reveals stable microbe-metabolite relationships in pediatric celiac disease.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Celiac disease is a lifelong immune-mediated disease triggered by dietary gluten and managed exclusively through a strict gluten-free diet. Differences in the gut microbiome are consistently observed in celiac disease, yet the associated metabolic consequences remain insufficiently defined. This study evaluated the stool microbiome-metabolome relationship in children from Canterbury, New Zealand, a region with a notably high prevalence of celiac disease (∼ 1 in 82). Eleven children with untreated celiac disease and 10 controls were assessed, with nine children resampled after 6 months of gluten-free diet adherence. Stool samples were subjected to 16S rRNA sequencing, targeted and untargeted metabolomic profiling, and multi-omics integration using cross-block and machine-learning approaches. Celiac disease was characterized by consistent reproducible changes in a small set of resampled-stable taxa and metabolites, rather than a uniform shift. The most prominent finding was rearrangement within
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