Evidence map›Paper›PMID 42577777›Full record

ArticleACS nano medicine2026

Revisiting Colloid Theory for Biomedicine: Reconciling Simple Models in Complex Environments.

Jin Gyun Lee, C Wyatt Shields

Abstract read
In one paragraph

Article in ACS nano medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jin Gyun LeeDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, United States.
C Wyatt ShieldsDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, United States.

Funding

Adoptive Macrophage Transfers for Nanoparticle DeliveryR35GM147455 · NIGMS · UNIVERSITY OF COLORADO · PI Charles Wyatt Shields IV · 2022 to 2026
$2.0M
NIGMS NIH HHS R35 GM147455
6 · The paper itself

Abstract

Colloidal science provides predictive frameworks for particle stability and interactions, yet applying these classical models to biological systems requires extending them to account for the complex and dynamic conditions present in physiological environments. Theories such as Derjaguin-Landau-Verwey-Overbeek (DLVO) were developed to describe interactions in carefully defined colloidal systems. When applied to biological environments, additional factors, including soft interfaces, evolving protein adsorption layers, and macromolecular crowding, must be incorporated to capture the full interaction landscape. Consequently, nanoparticles designed under traditional assumptions often behave unpredictably

Identifiers

PMID42577777
PMCPMC13455036

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.