Evidence map›Paper›PMID 42577832›Full record

ArticleMedical research archives2026

Dexpramipexole alleviates chronic allodynia from sciatic neuropathy and reduces spinal interferon-γ and other proinflammatory cytokines in spinal cord and dorsal root ganglia in mice.

Noah A Castro, Clara J Tomicek, Melody S Sun, Justine R Zimmerly, Annette K Fernandez-Oropeza, Sammy D Gomez-Medina, Zarena M Dominguez, Shahani Noor, Jessie R Maxwell, Erin D Milligan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical research archives, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noah A CastroDepartment of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Clara J TomicekDepartment of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Melody S SunDepartment of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Justine R ZimmerlyDepartment of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Annette K Fernandez-OropezaDepartment of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Sammy D Gomez-MedinaDepartment of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Zarena M DominguezDepartment of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Shahani NoorDepartment of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Jessie R MaxwellDepartment of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Erin D MilliganDepartment of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.

Funding

Understanding neurophysiological deficits in response inhibition in children with FASDP50AA022534 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Carlos Fernando Valenzuela · 2014 to 2026
$21.5M
Prenatal alcohol exposure generates vulnerability to the proinflammatory effects of morphine and adverse neuroimmune consequencesR01AA029694 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Shahani Noor · 2022 to 2026
$1.9M
Prenatal Alcohol Exposure Potentiates Pain via Lifelong Spinal-immune ChangesR01AA025967 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI MILLIGAN, ERIN DAMITA · 2017 to 2021
$1.5M
NIAAA NIH HHS P50 AA022534NIAAA NIH HHS R01 AA025967NIAAA NIH HHS R01 AA029694
6 · The paper itself

Abstract

Dexpramipexole is a small molecule compound with properties previously shown to block the voltage-gated sodium channel, Nav

Identifiers

PMID42577832
PMCPMC13455235

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.