Evidence map›Paper›PMID 42577896›Full record

ArticleJournal of human immunity2026

TCR γδ cell-specific STAT5 gain of function induces a druggable chronic human immune dysregulation.

Benedikt J Meyer, José Pedro Loureiro, Vladimir Nosi, Robin Hupfer, Adhideb Ghosh, Fabio Poletti, Annaïse Jauch, Julia Hirsiger, Caroline Berkemeier, Ingmar Heijnen and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Benedikt J Meyer *Immunodeficiency Laboratory, Department of Biomedicine, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0009-0003-4607-3766
José Pedro Loureiro *Experimental Immunology Laboratory, Department of Biomedicine, University of Basel and University Hospital, Basel, Switzerland.ORCID https://orcid.org/0000-0002-1744-6135
Vladimir NosiExperimental Immunology Laboratory, Department of Biomedicine, University of Basel and University Hospital, Basel, Switzerland.ORCID https://orcid.org/0009-0007-3759-9116
Robin HupferImmunodeficiency Laboratory, Department of Biomedicine, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0009-0003-0192-9540
Adhideb GhoshFunctional Genomics Center Zurich, ETH Zurich, and University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-5160-4571
Fabio PolettiImmunodeficiency Laboratory, Department of Biomedicine, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0009-0003-2499-2606
Annaïse JauchImmunodeficiency Laboratory, Department of Biomedicine, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0009-0004-8391-1666
Julia HirsigerTranslational Immunology Laboratory, Department of Biomedicine, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-1489-9323
Caroline BerkemeierLaboratory Medicine, Division Medical Immunology, University Hospital Basel, Basel, Switzerland.ORCID https://orcid.org/0009-0006-9072-2307
Ingmar HeijnenLaboratory Medicine, Division Medical Immunology, University Hospital Basel, Basel, Switzerland.ORCID https://orcid.org/0009-0001-1778-3748
Jan DirksLaboratory Medicine, Division Diagnostic Hematology, University Hospital Basel, Basel, Switzerland.ORCID https://orcid.org/0009-0003-7002-5932
Ilaria AlborelliPathology, Institute of Medical Genetics & Pathology, University Hospital Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0001-7849-3958
Thomas MenterPathology, Institute of Medical Genetics & Pathology, University Hospital Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-0847-6156
Alexandar TzankovPathology, Institute of Medical Genetics & Pathology, University Hospital Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-1100-3819
Christoph HessImmunobiology Laboratory, Department of Biomedicine, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0003-0364-8825
Alexander A NavariniDermatology and Skin Laboratory, Department of Biomedicine Basel, University Hospital Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0001-7059-632X
Christoph T BergerTranslational Immunology Laboratory, Department of Biomedicine, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-1730-8824
Lucia MoriExperimental Immunology Laboratory, Department of Biomedicine, University of Basel and University Hospital, Basel, Switzerland.ORCID https://orcid.org/0000-0002-5522-4648
Gennaro De LiberoExperimental Immunology Laboratory, Department of Biomedicine, University of Basel and University Hospital, Basel, Switzerland.ORCID https://orcid.org/0000-0003-0853-7868
Mike RecherImmunodeficiency Laboratory, Department of Biomedicine, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-9121-6936

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Within a prospective cohort of patients with immune dysregulation, we identified several individuals with chronically increased proportions of TCR γδ cells but normal peripheral lymphocyte counts. Among those, we identified one individual with a TCR γδ cell-specific heterozygous p.Y665F STAT5B gain-of-function mutation. Recurrent oral aphthous lesions, susceptibility to infection, arthralgia, and fatigue, were linked to relatively elevated numbers of γδ T cells expressing a Vγ9Vδ2 TCR, displaying hyperphosphorylation of STAT5 upon in vitro IL-2 stimulation. The TCR Vγ9Vδ2 cells exhibited enhanced proliferative response to (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate and dysregulated cytokine production. The TCR γδ cell transcriptome revealed the suppression of the default Th17 program, along with inhibition of

Identifiers

PMID42577896
PMCPMC13455652

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.