ReviewJournal of clinical medicine research2026
Circadian Rhythms in Colorectal Cancer: Recent Advances in Development and Treatment.
Review in Journal of clinical medicine research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian clock orchestrates biological rhythms across species and is deeply involved in the physiological and biochemical processes underlying tumor initiation and progression. By regulating cell division, DNA repair, immune function, and hormonal balance, circadian rhythms interact closely with cancer, providing a theoretical foundation for the exploration of chronotherapy. Maintaining circadian homeostasis is therefore essential for cancer prevention and treatment. This review centers on the intricate relationship between circadian rhythms and malignancy, with a particular focus on the role of circadian disruption in tumorigenesis and malignant progression. A systematic literature search was performed across the PubMed, MEDLINE, and Scopus databases to screen original studies and review articles focusing on circadian regulation in colorectal cancer. This review delineates the tissue-specific effects of circadian clock signaling in colorectal malignancy and clarifies the correlation between circadian disruption and early tumorigenesis. Accumulated evidence is integrated into a comprehensive mechanistic framework covering metabolic reprogramming, tumor immunosuppression, and stromal remodeling. Additionally, current advances in harnessing circadian rhythms to refine preventive strategies and chronotherapeutic regimens for colorectal cancer are highlighted, with a concise discussion on the potential of traditional Chinese medicine in regulating biological rhythms to improve colorectal cancer clinical management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.