ArticleScience progress
Association between frailty and clinical outcomes in critically ill coronary artery disease patients: A retrospective cohort study.
Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
ObjectiveFrailty is prevalent in cardiovascular disease but lacks objective assessment tools in critical care. This study evaluated the association between the Frailty Index based on laboratory data (FI-LAB) at ICU admission and clinical outcomes in critically ill patients with coronary artery disease (CAD).MethodsThis retrospective cohort study used data from the MIMIC-IV and MIMIC-III Carevue databases. Patients were stratified by FI-LAB into mild (<0.25), moderate (0.25-0.4), and severe (>0.4) frailty. Multivariable logistic regression assessed in-hospital mortality, Cox models evaluated 28-day and 1-year mortality, and Fine-Gray competing risk models examined malignant arrhythmia. Dose-response relationships and subgroup effects were also assessed.ResultsAfter full adjustment, severe frailty was associated with elevated in-hospital mortality (OR = 4.41, 95% CI: 2.60-7.48,
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