ArticlemSystems2026
Integrated multi-omics analysis identifies microbial and metabolic signatures and drivers of CNS autoimmunity.
Theresa L Montgomery, Emily A Nelson, Lauren A Downs, Eamonn R Heney, Margaret Frances J Lee, Cameron Martino, Daniel McDonald, Gibraan Rahman, Rob Knight, Dimitry N Krementsov
Abstract read
In one paragraphArticle in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Theresa L MontgomeryDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.ORCID 0000-0002-0950-9618 Emily A NelsonDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.
Lauren A DownsDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.
Eamonn R HeneyDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.
Margaret Frances J LeeDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.
Cameron MartinoLeaven Foods Inc., San Diego, California, USA.
Daniel McDonaldDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.
Gibraan RahmanDepartment of Pediatrics, University of California, San Diego, La Jolla, California, USA.
Dimitry N KrementsovDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.ORCID 0000-0003-2709-7466 Funding
Vermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8MVermont Immunology/Infectious Diseases Training GrantT32AI055402 · NIAID · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI GARY E WARD · 2005 to 2026
$2.7MInteractions Between Host Genetics and the Gut Microbiome in CNS AutoimmunityR01NS097596 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KREMENTSOV, DIMITRY N · 2017 to 2021
$1.7MAcquisition of a new Flow CytometerS10OD026843 · OD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOYSON, JONATHAN E · 2019 to 2019
$204kMechanisms Underlying Regulation of Susceptibility to CNS Autoimmunity by Commensal Lactobacillus SpeciesF31NS120381 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MONTGOMERY, THERESA LYNN · 2021 to 2022
$30kNational Multiple Sclerosis Society RG-2407-43682NIAID NIH HHS T32 AI055402NIGMS NIH HHS P30 GM118228NIH HHS S10 OD026843NINDS NIH HHS F31 NS120381NINDS NIH HHS F31NS120381-01A1NINDS NIH HHS R01 NS097596
6 · The paper itselfAbstract
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), driven by genetic and environmental determinants. The gut microbiome of people with MS (pwMS) is distinct and influences disease through immunomodulatory metabolite production. Circulating metabolites are altered in pwMS, but identifying microbial-metabolic drivers remains challenging. We previously showed that colonization by the gut commensal
Indexed as
AutoimmunityCentral Nervous SystemEncephalomyelitis, Autoimmune, ExperimentalGastrointestinal MicrobiomeMetabolomeMultiple SclerosisAnimalsDietFemaleLimosilactobacillus reuteriMetabolomicsMiceMice, Inbred C57BLMultiomicsTryptophanTryptophancresolindoleLimosilactobacillus. reuterimetabolomicsmicrobiomemulti-omicsmultiple sclerosis
Identifiers
PMID42578693
PMCPMC13595924
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