ArticleBiotechnology letters2026
Impact of acetaminophen on the growth kinetics and metabolite production of probiotic lactic acid bacteria.
Article in Biotechnology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Bacterial interactions within the human gut microbiota are dynamic and closely linked to host health. These interactions are time-dependent and can be modulated by probiotic bacteria through metabolite production, environmental modification such as pH changes, and niche occupation. However, commonly used human-targeted drugs may alter these microbial dynamics. This study evaluated the effect of acetaminophen, a widely used over-the-counter drug, on the growth dynamics of a probiotic lactic acid bacterium within synthetic gut microbiota communities. The growth of Lactococcus lactis subsp. lactis was analyzed in monoculture and in co-culture with the commensal species Clostridium butyricum using 2 mL batch microbioreactors. Biomass accumulation was monitored until stationary phase, while acetaminophen and lactic acid concentrations were quantified by LC-MS. Growth kinetics were characterized using four parameters: carrying capacity, biomass accumulation (AUC), maximum growth rate (
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