Evidence map›Paper›PMID 42579228›Full record

ArticleAnnals of biomedical engineering2026

Second Harmonic Generation Imaging Links Collagen Structure and Biochemical Composition in Human Osteoarthritic Cartilage.

Ziad Abusara, Eng Kuan Moo, Benafsha Tughra, Venus Joumaa, Azim Jinha, Sue Miller, Scott Timmermann, Walter Herzog

Abstract read
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In one paragraph

Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ziad AbusaraHuman Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada. zabusara@ucalgary.ca.
Eng Kuan MooHuman Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.ORCID http://orcid.org/0000-0001-6363-6063
Benafsha TughraHuman Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.
Venus JoumaaHuman Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.
Azim JinhaHuman Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.
Sue MillerCumming School of Medicine, McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Canada.
Scott TimmermannCumming School of Medicine, McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Canada.
Walter HerzogHuman Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.

Funding

Canada Foundation for Innovation 395128CIHR PJT-183834NSERC Alliance grant 320208NSERC Discovery grant DGECR-2023-00346The Arthritis Society S0G-10-0521the Carleton University research fund 186725the Carleton University research fund 187023
6 · The paper itself

Abstract

Articular cartilage is a highly hydrated, collagen-rich tissue that plays a critical role in joint function. Early degenerative changes in osteoarthritis (OA) are associated with alterations in collagen organization that precede gross structural damage; however, current imaging modalities, including radiography, computed tomography, and magnetic resonance imaging, often lack sufficient sensitivity to detect these microstructural changes. Second harmonic generation (SHG) imaging is a label-free optical technique sensitive to collagen microstructure. Previously, we developed an image-based parameter, the volumetric fraction of organized collagen (Φ

Indexed as

CollagenHuman articular cartilageHydroxyprolineMultiphoton microscopyOsteoarthritisSecond harmonic generationStreaming potential

Identifiers

PMID42579228

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.