Evidence map›Paper›PMID 42579492›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

AAV-NRF2 protects retinal and choroidal vasculature in a GDF15-dependent manner in an oxidative damage model of AMD.

Shuai Wang, Sophia Zhao, Adam Daniels, Efrat Naaman, Apolonia Gardner, Lois E H Smith, Constance L Cepko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuai WangDepartments of Genetics and Ophthalmology, Harvard Medical School, Boston, MA 02115.
Sophia ZhaoDepartments of Genetics and Ophthalmology, Harvard Medical School, Boston, MA 02115.
Adam DanielsDepartments of Genetics and Ophthalmology, Harvard Medical School, Boston, MA 02115.
Efrat NaamanDepartments of Genetics and Ophthalmology, Harvard Medical School, Boston, MA 02115.
Apolonia GardnerDepartments of Genetics and Ophthalmology, Harvard Medical School, Boston, MA 02115.
Lois E H SmithDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-7644-6410
Constance L CepkoDepartments of Genetics and Ophthalmology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-9945-6387

Funding

Howard Hughes Medical Institute (HHMI) NA
6 · The paper itself

Abstract

Oxidative stress is proposed to be a driver of age-related diseases. Age-related macular degeneration (AMD) is one such disease, where the retinal pigment epithelium (RPE) is affected early in the disease. Vasculature damage also occurs, sometimes preceding RPE damage. To model some aspects of dry AMD, we used the NaIO

Indexed as

ChoroidDependovirusGrowth Differentiation Factor 15Macular DegenerationNF-E2-Related Factor 2Oxidative StressRetinal VesselsAnimalsDisease Models, AnimalMiceRetinal Pigment EpitheliumGrowth Differentiation Factor 15Nfe2l2 protein, mouseNF-E2-Related Factor 2choriocapillarisGDF15NRF2retinal pigment epitheliumretinal vasculature

Identifiers

PMID42579492
PMCPMC13486614

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.