ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
VlPAG/DRN Microglia Drive Neuropathic Pain-Induced Depression via a Defined Neuroimmune Axis.
Jing Yang, Bing-Jie Tang, Jia-Yi Li, Shu-Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen-Zhong Xu
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In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
Jing YangDepartment of Anesthesiology of First Affiliated Hospital, and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Bing-Jie TangDepartment of Anesthesiology of First Affiliated Hospital, and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Jia-Yi LiSchool of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Shu-Lan XieDepartment of Anesthesiology of First Affiliated Hospital, and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Shumin DuanDepartment of Anesthesiology of First Affiliated Hospital, and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Shengmei ZhuDepartment of Anesthesiology of First Affiliated Hospital, and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, China.ORCID https://orcid.org/0000-0002-1877-9812 Zhen-Zhong XuDepartment of Anesthesiology of First Affiliated Hospital, and Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, China.ORCID https://orcid.org/0000-0001-6578-211X Funding
Brain Science and Brain-like Intelligence Technology-National Science and Technology Major Project 2021ZD0202703Fundamental Research Funds for Central Universities 2023ZFJH01-01Fundamental Research Funds for Central Universities 2024ZFJH01-01Fundamental Research Funds for Central Universities 226-2022-00227MOE Frontier Science Center for Brain Science & Brain-Machine Integration, Zhejiang UniversityNanhu Brain-Computer Interface Institute 04202508016National Natural Science Foundation of China 32571181National Natural Science Foundation of China 82171206National Natural Science Foundation of China 82301397Natural Science Foundation of Ningbo Municipality 2025J032Ningbo Medical and Health Brand Discipline PPXK2024-05Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences 2023-PT310-01Zhejiang Provincial Natural Science Foundation of China LZ25H090001
6 · The paper itselfAbstract
Neuropathic pain is frequently comorbid with anxiety and depression, yet the mechanisms linking immune signaling to affective brain circuits remain poorly understood. Here, we identify a neuroimmune circuit in which peripheral nerve injury activates microglia in the midbrain ventrolateral periaqueductal gray/dorsal raphe (vlPAG/DRN), triggering an NLRP3-IL-1β-dependent inflammatory cascade. Direct optogenetic or chemogenetic activation of vlPAG/DRN microglia is sufficient to drive negative affective behaviors. We show that local VGLUT2
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biologychemistrymedicine
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PMID42579561
PMCPMC13460408
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