Evidence map›Paper›PMID 42580708›Full record

ArticleSchizophrenia bulletin2026

Association Between Social and Role Functioning and Transition to Psychosis in the North American Prodrome Longitudinal Study Consortium.

Jean Addington, Monica Chu, Lu Liu, Robert Heinssen, Andrea Auther, Carrie E Bearden, Tyrone D Cannon, Ricardo E Carrión, Matcheri Keshevan, Daniel H Mathalon and 7 more

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PubMed Full text at PMC Publisher
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Article in Schizophrenia bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jean AddingtonDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4Z6, Canada.
Monica ChuDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4Z6, Canada.
Lu LiuDepartment of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4Z6, Canada.
Robert HeinssenIndependent Scholar, Garrett Park, MD 20896, United States.
Andrea AutherNorthwell, Glen Oaks, NY 11004, United States.
Carrie E BeardenDepartments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA 90095, United States.ORCID 0000-0002-8516-923X
Tyrone D CannonDepartment of Psychology, Yale University, New Haven, CT 06510, United States.
Ricardo E CarriónNorthwell, Glen Oaks, NY 11004, United States.ORCID 0000-0002-6393-392X
Matcheri KeshevanDepartment of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts Mental Health Centre, Boston, MA 02115, United States.
Daniel H MathalonDepartment of Psychiatry, UCSF, and SFVA Medical Center, San Francisco, CA 94121, United States.
Thomas H McGlashanDepartment of Psychiatry, Yale University, New Haven, CT 06519, United States.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC 27514, United States.
William S StoneDepartment of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts Mental Health Centre, Boston, MA 02115, United States.ORCID 0000-0003-2932-7288
Ming T TsuangDepartment of Psychiatry, UCSD, La Jolla, CA 92104, United States.
Elaine F WalkerDepartments of Psychology and Psychiatry, Emory University, Atlanta, GA 30322, United States.ORCID 0000-0002-9798-8101
Scott W WoodsDepartment of Psychiatry, Yale University, New Haven, CT 06519, United States.
Kristin S CadenheadDepartment of Psychiatry, UCSD, La Jolla, CA 92104, United States.ORCID 0000-0002-5952-4605

Funding

STRESS AND EMOTIONAL REACTIVITYP50MH066286 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 2003 to 2014
$18.6M
1/9 Predictors and Mechanisms of Conversion to PsychosisU01MH081902 · NIMH · YALE UNIVERSITY · PI CANNON, TYRONE D · 2008 to 2018
$12.4M
Vulnerability to Progression SchizophreniaP50MH080272 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WOO, TSUNGUNG · 2007 to 2011
$9.9M
5/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082004 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PERKINS, DIANA O. · 2008 to 2018
$7.5M
Administrative Supplement Harmonization of At Risk Multisite Observational Networks for Youth(HARMONY)U01MH081928 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI STONE, WILLIAM SETH · 2008 to 2018
$7.1M
4/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081857 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CORNBLATT, BARBARA A. · 2008 to 2018
$6.2M
8/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082022 · NIMH · YALE UNIVERSITY · PI WOODS, SCOTT W · 2008 to 2018
$6.0M
2/9 - Predictors and Mechanisms of Conversion to PsychosisU01MH081988 · NIMH · EMORY UNIVERSITY · PI WALKER, ELAINE FRAN · 2008 to 2018
$5.4M
6/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081944 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2008 to 2018
$4.9M
"7/9" Predictors and Mechanisms of Conversion to PsychosisU01MH081984 · NIMH · UNIVERSITY OF CALGARY · PI ADDINGTON, JEAN M · 2008 to 2018
$4.2M
Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for PsychosisR01MH123641 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2021 to 2024
$4.0M
VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIAR01MH060720 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2000 to 2010
$4.0M
Commonwealth of Massachusetts K24 MH76191Commonwealth of Massachusetts P50 MH066286Commonwealth of Massachusetts R01MH60720Commonwealth of Massachusetts SCDMH82101008006Commonwealth of Massachusetts U01 MH081902Commonwealth of Massachusetts U01MH082022NIMH NIH HHS K24 MH076191NIMH NIH HHS P50 MH066286NIMH NIH HHS P50 MH080272NIMH NIH HHS R01 MH060720NIMH NIH HHS R01 MH123641NIMH NIH HHS R01MH123641NIMH NIH HHS U01 MH076989NIMH NIH HHS U01MH076989NIMH NIH HHS U01 MH081857NIMH NIH HHS U01 MH081902NIMH NIH HHS U01MH081902NIMH NIH HHS U01 MH081928NIMH NIH HHS U01MH081928NIMH NIH HHS U01 MH081944NIMH NIH HHS U01MH081944NIMH NIH HHS U01 MH081984NIMH NIH HHS U01MH081984NIMH NIH HHS U01 MH081988NIMH NIH HHS U01MH081988NIMH NIH HHS U01 MH082004NIMH NIH HHS U01MH082004NIMH NIH HHS U01 MH082022NIMH NIH HHS U01MH082022NIMH NIH HHS UO1MH081857Shear Family Foundation and the Don S. Levin Trust U01 MH081857-05Shear Family Foundation and the Don S. Levin Trust U01 MH081988Shear Family Foundation and the Don S. Levin Trust U01 MH082004Shear Family Foundation and the Don S. Levin Trust U01 MH082022Staglin Family Music Festival for Mental Health
6 · The paper itself

Abstract

background and hypothesisFunctional deficits during adolescence have proved to be important risk factors for later psychosis at 2 to 3-year follow-up. The aim of the current study was to evaluate whether social and role functioning in clinical high-risk (CHR) youth is associated with transition to psychosis. STUDY

designData from the North American Prodrome Longitudinal Studies (NAPLS 2, NAPLS 3) were combined with outcome data from the NAPLS Long-Term Follow-up study to assess the relationship between baseline social and role functioning and later transition to psychosis. Participants included 1474 CHR individuals from NAPLS 2 (n = 764) and NAPLS 3 (n = 710), of whom 198 (13%) are known to have transitioned to psychosis. STUDY

resultsIndividuals who later transitioned to psychosis had more severe positive and negative symptoms and poorer social and role functioning at baseline compared to those who did not. Higher baseline social and role functioning was significantly associated with a reduced hazard of transition (HR = 0.864, P = .0013; HR = 0.898, P = .0004, respectively), whereas a decline in social and in role functioning was significantly associated with an increased hazard of transition (HR = 1.229, P = .0013; HR = 1.124, P = .002, respectively).

conclusionsThese results underscore the significance of social and role functioning in predicting subsequent transition to psychosis in CHR participants, suggesting an underlying vulnerability that is possibly independent of clinical symptoms. Early intervention that includes a focus on social and role functioning in high-risk youth may reduce the risk of future functional disability and perhaps a later psychotic episode.

Indexed as

Disease ProgressionProdromal SymptomsPsychosocial FunctioningPsychotic DisordersRoleAdolescentFemaleHumansLongitudinal StudiesMaleNorth AmericaYoung Adultclinical high-riskglobal functioning: Roleglobal functioning: Socialsocial functioningtransition to psychosisultra-high-risk

Identifiers

PMID42580708
PMCPMC13461213

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.